くすりのしおり

Internal
Revised: 3/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
PHOSBLOCK TABLETS 250mg
 Active ingredient:
Sevelamer hydrochloride
 Dosage form:
white to faintly yellowish white tablet, diameter: 9 mm, thickness: 6.2 mm
 Print on wrapping:
フォスブロック250, PHOSBLOCK250, KR01

Effects of this medicine

This medicine binds to phosphorus contained in food in the gastrointestinal tract to promote the fecal excretion of phosphorus. It consequently suppresses gastrointestinal absorption of phosphorus and decreases blood phosphorus concentration.
It is usually used to improve hyperphosphatemia occurred in chronic renal failure patient on dialysis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have intestinal obstruction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 4 to 8 tablets (1 to 2 g of the active ingredient) at a time, 3 times a day just before meals. The dosage may be adjusted according to your age, symptoms and serum phosphorus concentration. However, the maximum daily dose is 36 tablets (9 g). Strictly follow the instructions.
  • Take it with water or lukewarm water, without keeping in the mouth for a long time or chewing. If it is difficult to take all the tablets at once, take in several batches.
  • If you miss a dose and realize it during or just after meals, take the missed dose as soon as possible. Otherwise, skip the missed dose and take the next dose before the next meal. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include constipation/ aggravated constipation, abdominal pain, abdominal distension, nausea, indigestion, and diarrhea/loose stool. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • severe constipation, persistent abdominal pain, vomiting [intestinal tract perforation, intestinal obstruction]
  • tenderness in lower abdomen, fever, melena [diverticulitis, ischemic enteritis]
  • vomiting of blood, melena, nausea/vomiting [gastrointestinal bleeding, gastrointestinal ulcer]
  • general malaise, loss of appetite, yellowing of the skin and the white of eyes [hepatic function disorder]
  • constipation, worsening of constipation, abdominal pain, abdominal bloating [constipation, aggravated constipation, abdominal pain, abdominal distension]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.