Search results detail| Kusurino-Shiori(Drug information Sheet)

Kyowa Hakko Kirin Co.,Ltd

Injection
Revised: 2/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

Brand name :

NESP INJECTION 40mcg PLASTIC SYRINGE[anemia with myelodysplastic syndromes]

　Active ingredient:

Darbepoetin Alfa(Genetical Recombination)

　Dosage form:

injection

　Print on wrapping:

Effects of this medicine

This medicine acts on cells that grow into red blood cells (RBCs) to increase the number of RBCs.
It is usually used in the treatment of anemia with myelodysplastic syndromes.

Before using this medicine, be sure to tell your doctor and pharmacist

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have a history of myocardial infarction, pulmonary infarction or cerebral infarction.
If you have: hypertension.

If you are pregnant or breastfeeding.

If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

Your dosing schedule prescribed by your doctor is (( to be written by a healthcare professional))

In general, for adults, inject subcutaneously once per week. Ask your doctor about the dosing instructions.
You will be administered this medicine over a long time under the monitoring of efficacy.
If you use this medicine for the first time or after an interval, you may be administered lower dose subcutaneously and observed whether any abnormalities occur.

Precautions while taking this medicine

You need to take iron to get an adequate efficacy. If you are prescribed iron preparation, you should take it as instructed by your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, headache and hypertension. If any of these symptoms occur, consult with your doctor or pharmacist.

The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

paralysis of face and limbs on one side, numbness, language disorder such as inarticulateness [cerebral infarction]
headache, dizziness, nausea [cerebral hemorrhage]
general malaise, loss of appetite, yellowing in skin and white of eyes [hepatic function disorder, jaundice]
headache, disturbed consciousness, convulsion [hypertensive encephalopathy]
urticaria, dyspnea, lip edema, pharyngeal edema (swelling of lips or throat) [shock, anaphylaxis]
pallor, general malaise, palpitation or shortness of breath in climbing up stairs or walking up a slope [pure red-cell aplasia]
chest pain, cold sweat, chest pressure [myocardial infarction]
chest pain, dyspnea, disturbed consciousness [pulmonary infarction]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.