くすりのしおり

Injection
Revised: 2/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Navelbine Injection 10
 Active ingredient:
Vinorelbine ditartrate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine exerts an anti-tumor effect by stopping the function of microtubules that play an important role in cell division.
It is usually used for the treatment of non-small cell lung cancer, and inoperable or recurrent breast cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have decrease in bone marrow function, infections, liver disorder, history of interstitial pneumonia or pulmonary fibrosis, neurological or muscular diseases or history of these conditions, ischemic heart disease or history of this condition, or a tendency for constipation.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Non-small cell lung cancer: In general, for adults, this medicine is administered intravenously once a week.
    Inoperable or recurrent breast cancer: In general, this medicine is administered intravenously once a week for 2 consecutive weeks, then discontinued in the third week.
    In any case, the dosage intervals depend on concomitant medicines or symptoms/conditions. Ask your doctor about your dosing schedule.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include bone marrow depression, loss of appetite, general malaise, alopecia, nausea, fever, vomiting, phlebitis, stomatitis, constipation, diarrhea, paresthesia/reduced tendon reflexes, and allergy-like symptoms. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • general malaise, bruise, dizziness [myelosuppression (leukopenia, anemia, and thrombocytopenia)]
  • fever, headache, breathing difficulty [interstitial pneumonia, pulmonary edema]
  • wheezing, crowing sound when breathing, sudden shortness of breath [bronchospasm]
  • intense abdominal pain, abdominal bloating, no output of stool [paralytic ileus]
  • general malaise, breathing difficulty, feeling of tight chest [cardiac failure, myocardial infarction, angina pectoris]
  • rash, breathing difficulty, decreased blood pressure [shock, anaphylaxis]
  • fever, cough, chest pain, breathing difficulty [pulmonary embolism]
  • convulsion, impaired consciousness, loss of appetite [syndrome of inappropriate antidiuretic hormone secretion]
  • general swelling, fatigability, difficulty in urination [acute renal failure]
  • sudden intense pain in low back and back, fever, nausea/vomiting [acute pancreatitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.