くすりのしおり

Injection
Revised: 7/2012

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
FRAGMIN IV 5000IU/5mL [Hemodialysis]
 Active ingredient:
Dalteparin sodium
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine prevents the formation of blood clots by making blood less likely to clot while suppressing the risk of bleeding.
It is usually used to prevent coagulation of blood circulating in the dialysis circuit during hemodialysis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have, or have a history of bleeding (due to conditions other than disseminated intravascular coagulation), heparin-induced thrombocytopenia or liver disorder.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject this medicine once into the dialyzer at the beginning of dialysis. After initiating dialysis, inject this medicine continuously from a dedicated inlet (anticoagulant injection line).
  • This medicine is used when hemodialysis is performed.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include bleeding adverse reactions, itchiness, fever and rash. If any of these symptoms occurs, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occurs, stop taking this medicine and see your doctor immediately.
  • edema, decreased blood pressure, respiratory distress [shock, anaphylactoid symptoms]
  • headache, black stool, nasal bleeding [bleeding]
  • nasal bleeding, gum bleeding, bruise [thrombocytopenia]
  • acute respiratory distress, disturbance of consciousness, convulsion [thrombosis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Patients receiving dialysis on an outpatient basis should make sure that the bleeding at the site of puncture has stopped before they go home.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.