くすりのしおり

Internal
Revised: 1/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
HYDREA CAPSULES 500 mg
 Active ingredient:
Hydroxycarbamide
 Dosage form:
purplish red opaque/bluish green opaque hard capsule, major axis: 21.0 mm, minor axis: 7.6 mm
 Print on wrapping:
(Face) HYDREA 500 mg, BMS 303, (Back) ハイドレア カプセル 500 mg, ハイドレア 500mg

Effects of this medicine

This medicine suppresses the abnormal proliferation of immature bone marrow by inhibiting cellular DNA synthesis.
It is usually used for chronic myeloid leukemia, essential thrombocythemia and polycythemia vera.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have impaired renal/hepatic function, low level of white blood cells or other blood components, cold or chicken pox.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 to 4 capsules (500 to 2,000 mg of the active ingredient) in 1 to 3 divided doses a day. For maintenance after remission, take 1 or 2 capsules (500 to 1,000 mg) in 1 or 2 divided doses a day. The initial dose or maintenance dose may be adjusted according to the symptoms, age or body weight. Strictly follow the instructions.
  • If you missed a dose, take the prescribed dosage when you notice. You can take more than one dose within the day you missed a dose, but you should never take two-days doses at one time. Take the next dose at the prescribed schedule.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Visit your doctor regularly to check the effects or adverse reactions of this medicine.
  • If you or your partner have a possibility of pregnancy, avoid pregnancy while you are taking this medicine and for a certain period after you discontinue this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash/eruption, nausea/vomiting, and anemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • fever, chill, cough, nasal discharge, dizziness, bleeding tendency, continuous bleeding, bruise, dullness, easy faigability, shortness of breath, sore throat [bone marrow depression]
  • fever, cough, breathing difficulty [interstitial pneumonia]
  • lower limbs ulcer [skin ulcer]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from light, heat and moisture.
  • Discard the remainder. Do not store them. Ask your pharmacist or healthcare facility how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.