Before using this medicine, be sure to tell your doctor and pharmacist
- If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have previously experienced rash or itch after administrating any other medicines which increase leukocytes.
Patients with the following underlying diseases may cause serious adverse effects (quotation from the guideline of Japan Society for Hematopoietic Stem Cell Transplantation explanatory material in obtaining consent from allogeneic peripheral blood stem cell donors):
If you have previously been told that your blood is prone to form blood clot or your blood vessels are prone to clog (hypertension, cardiac disease, a history of cerebral infarction, diabetes mellitus or hyperlipidemia).
If you have splenomegaly; cardiac disease, lung disease or renal disease which is required to be treated; autoimmune disease, inflammatory disease, hepatic dysfunction or neurological disorder.
If you are suspected to have bone marrow disease such as leukocytosis and thrombocytosis.
If you have interstitial pneumonia or a history of it.
If you have a history of cancer.
- If you are pregnant, may be pregnant or breastfeeding.
- If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include lumbar pain, headache, arthralgia, fever, bone pain (chest, lumbar region, pelvis, etc.) and abnormal hepatic function. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- chilliness, palpitation, cold sweat, grow pale [shock, anaphylaxis]
- fever, dry cough, difficult to breathe [interstitial pneumonia]
- hard to breathe, rapid breathing, lips turn blue, nails and toenails turn blue [acute respiratory distress syndrome]
- left upper quadrant pain, abdominal bloating [splenic rupture]
- sudden pressurized feeling in chest, anginal pain, cold sweat, fear of death [myocardial infarction (quotation from the guideline of Japan Society for Hematopoietic Stem Cell Transplantation "explanatory material in obtaining consent from allogeneic peripheral blood stem cell donors")]
- headache, feeling unwell, vomiting, decreased consciousness, hemiparesis, difficult to speak [cerebrovascular disorder (quotation from the guideline of Japan Society for Hematopoietic Stem Cell Transplantation "explanatory material in obtaining consent from allogeneic peripheral blood stem cell donors")]
- hypotension, edema, rapid weight increase [capillary leak syndrome]
- fever, general malaise, headache, dizziness [large vessel vasculitis (inflammation of aorta, common carotid artery, subclavian artery, etc.)]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.