くすりのしおり

Internal
Revised: 11/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Kiklin Capsules 250 mg
 Active ingredient:
Bixalomer
 Dosage form:
pale yellow capsule, capsule size 1, 19.4 mm
 Print on wrapping:
(Face) キックリン 250mg, キックリン, 250mg, アステラス製薬, (Back) Kiklin 250, キックリン, 250mg, house-mark, アステラス製薬

Effects of this medicine

This medicine decreases blood concentration of phosphorus by binding to phosphate in the gastrointestinal tract to promote phosphate excretion into the feces and thus inhibiting the absorption of phosphate from the gastrointestinal tract.
It is usually used for the treatment of hyperphosphatemia with chronic kidney disease.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have intestinal obstruction.
    If you have constipation tendency.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start with 2 capsules (500 mg of the active ingredient), three times a day, immediately before each meal. The dose may be adjusted according to the symptom or the phosphorus concentration level in the blood. The maximum daily dose should not exceed 30 capsules (7,500 mg). Strictly follow the instructions.
  • If you miss a dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Aggravated constipation and/or abdominal bloating may occur. Monitor daily bowel movements.
  • Restrict phosphorus intake from food.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include constipation, hard stool, stomach discomfort, itch, abdominal bloating, abdominal pain and nausea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • abdominal pain, nausea, vomiting, abdominal bloating, stoppage of defecation [intestinal perforation, intestinal obstruction]
  • acute abdominal pain, melena, fever, nausea, vomiting [ischemic enterocolitis]
  • epigastric pain, heartburn, belching, nausea, vomiting, abdominal pain, vomiting of blood, melena, black stool [gastrointestinal bleeding, gastrointestinal ulcer]
  • lack or prolonged absence of bowel movements [constipation/aggravated constipation]
  • lower abdominal pain, fever [diverticulitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.