くすりのしおり

Internal
Revised: 9/2013

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
RIZABEN Cap. 100mg
 Active ingredient:
Tranilast
 Dosage form:
white capsule, major axis: 15.8 mm, minor axis: 5.8 mm
 Print on wrapping:
リザベン100mg, RZ, RIZABEN, アレルギー性疾患治療剤, ケロイド・肥厚性瘢痕治療剤

Effects of this medicine

This medicine inhibits chemical mediator release to show antiallergic and anti-inflammatory effect. It also inhibits cytokine (TGF-β1) release to suppress collagen synthesis in fibroblast cell.
It is usually used to treat bronchial asthma, allergic rhinitis, atopic dermatitis, keloid or hyperplastic scar.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are a patient with liver or kidney disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for dosage regimen: For adults, take 1 capsule (100 mg of the active ingredient) at a time, 3 times a day. The dosage should be adjusted according to the disease, age or symptoms. Strictly follow the instructions of your doctor and pharmacist.
  • If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea, abdominal pain, discomfort in stomach, loss of appetite, diarrhea, rash and frequent urination. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • urine frequency, pain on urination, hematuria  [cystitis like symptoms]
  • general malaise, yellowing of skin or conjunctiva, loss of appetite  [hepatic dysfunction, jaundice]
  • decrease of urine output, swelling in hand or feet  [renal dysfunction]
  • fever, gum bleeding, bleeding from nose [leukopenia, thrombocytopenia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from direct sunlight and heat.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.