くすりのしおり

Internal
Revised: 3/2010

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
METALCAPTASE cap. 100mg
 Active ingredient:
Penicillamine
 Dosage form:
opaque capsule with red cap and pale yellow body
 Print on wrapping:
T651

Effects of this medicine

This medicine relieves pain/stiffness in rheumatoid arthritis patients by immunomodulatory effect. It also improves the symptoms caused by heavy-metal accumulation by its effect of binding with heavy-metal such as copper, mercury or lead and draining them out of the body.
It is usually used to treat rheumatoid arthritis, Wilson's disease or copper/mercury/lead intoxication.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you are a patient with blood disorder, renal disorder, systemic lupus erythematosus, loss of marrow function, poor general status or hepatic disorder.
    If you are a growing child and have metabolism disorder of connective tissue.
    If you are just after having surgery.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General dosage regimen:
    For treatment of rheumatoid arthritis, for adults
    , take 1 capsule (100 mg of the active ingredient) at a time, 1-3 times a day between meals on an empty stomach. The dosage should be adjusted according to your age, symptoms, tolerability or response to the medicine. Generally, start with taking 1 capsule (100 mg), increase it by 1 capsule (100 mg) at intervals of 4 weeks or more and then the maintenance dose is determined. If daily dose of 3 capsules (300 mg) is insufficient, it may be increased up to 6 capsules (600 mg). Strictly follow the instructions of your doctor/pharmacist.
    For treatment of Wilson's disease or copper/mercury/lead intoxication (adults)
    , take 10 capsules (1,000 mg of the active ingredient) a day in one to several divided doses before meals on an empty stomach. The dosage should be adjusted according to the disease to be treated, age, symptoms, tolerability or response to the medicine in the range of 6-14 capsules (600-1,400 mg) a day. Strictly follow the instructions of your doctor/pharmacist.
    For copper/mercury/lead intoxication (children)
    , take 20-30 mg of the active ingredient per 1 kg of the body weight a day, before meals on an empty stomach. The dosage should be adjusted according to the disease to be treated, age, symptoms, tolerability or response to the medicine up to 10 capsules (1,000 mg) a day. Strictly follow the instructions of your doctor/pharmacist.
  • Consult with your doctor/pharmacist as soon as possible. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking the medicine without the instructions of your doctor.

Precautions while taking this medicine

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: rash, itch, taste abnormality, abdominal pain, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • gerenal malaise, headache, nasal/gum bleeding  [severe blood disorder such as agranulocytosis]
  • swelling, decrease of urine output, breathing difficulty  [nephrotic syndrome (membranous nephropathy,etc.)]
  • taste diminished, taste loss, taste differency (not tasting properly, tasting differently from the original)  [taste anesthesia]
  • systemic blisters appearing on the skin or on the mucous membrane, blisters may be easily broken, severe itchiness throughout the body  [pemphigus like symptoms]
  • symmetric muscle weakness seen in the neck or limbs, swallowing disorder, rash  [polymyositis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.