くすりのしおり

Internal
Revised: 10/2013

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
NIFELANTERN CR TABLETS 20
 Active ingredient:
Nifedipine
 Dosage form:
pale red tablet, φ:7.8 mm, thickness:4.3 mm
 Print on wrapping:
ニフェランタンCR錠20, ZE102, NFL20, NIFELANTERN CR20, ニフェランタンCR, 20mg

Effects of this medicine

This medicine suppresses calcium ion influx into cells which causes contraction of the heart and vessels, to dilate the coronary vessel and to decrease total peripheral vascular resistance. It consequently shows antihypertensive effects and antianginal effects.
It is usually used for the treatment of hypertension, renal hypertension and angina.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are a patient with heart disease.
  • If you are pregnant, possible pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For hypertension: In general, for adults, take 20 to 40mg of the active ingredient at a time, once a day. However, the initial dose is started at 10 to 20mg, then the dosage may be gradually increased as necessary. In case of uncontrolled with 2 tablets (40mg) once a day, the dosage may be increased to 2 tablets (40mg) at a time, twice a day.
    For renal parenchymal hypertension, renovascular hypertension: In general, for adults, take 20 to 40mg of the active ingredient at a time, once a day. However, the initial dose is started at 10 to 20mg, then the dosage may be gradually increased as necessary.
    For angina, variant angina:
    In general, for adults, take 2 tablets (40mg of the active ingredient) at a time, once a day. The dosage may be adjusted according to the symptoms, however, the maximum daily dose is 3 tablets (60mg) at a time, once a day. This preparation contains 20mg of the active ingredient in a tablet. Strictly follow the instructions in any case.
  • Never split, crush, or grind the medicine. Swallow it without chewing.
  • If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Avoid drinking grapefruit juice with the medicine. It may enhance the effect of the medicine.
  • You may feel dizziness/stagger due to decreased blood pressure. Do not drive a car, work at heights, or operate dangerous machinery while taking this medicine.
  • In rare cases, when you defecated shortly after taking the medicine, it may be excreted in unchanged form due to your medical condition (such as diarrhea). In such case please consult with your doctor or pharmacist.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include jaundice, chest pain, upper abdominal pain, rash, itch, photosensitivity, purpura, angioedema, swollen gum, anemia, breathing difficulty and gynecomastia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • systemic red rash, skin exfoliation, fever  [erythroderma (exfoliative dermatitis)]
  • sore throat, fever (hyperthermia), muscle pain  [agranulocytosis]
  • nasal bleeding, gum bleeding, subcutaneous hemorrhage in limbs [thrombocytopenia]
  • generalized fatigability, nausea, yellowness in skin or conjunctiva  [liver dysfunction, jaundice]
  • faint consciousness, loss of concentration, judgment failure  [impaired consciousness]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from light, heat and moisture.
  • Do not store the remainder and consult your pharmacy or medical institution how to discard it.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.