くすりのしおり

Internal
Revised: 10/2009

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
RELIFEN Tablets 400mg
 Active ingredient:
Nabumetone
 Dosage form:
white-yellowish white tablet, φ 11.1 mm, thickness 5.6 mm
 Print on wrapping:
RELIFEN 400, REL 400, Sc102, レリフェン錠400mg, レリフェン, 400mg

Effects of this medicine

This medicine shows antiinflammatory and analgesic effect by inhibiting synthesis of prostaglandin.
It is usually used for antiinflammation and analgesia with rheumatoid arthritis, osteoarthritis, low back pain, cervico-omo-brachial syndrome, and scapulohumeral periarthritis. However, this medicine is not effective for cure diseases themselves.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you have peptic ulcer, or have history of peptic ulcer.
    If you are a patient with blood abnormality, liver/kidney disorder, aspirin-induced asthma, heart disease, bronchial asthma.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General dosage regimen: For adults, take 2 tablets (800 mg of the active ingredient) at a time, once daily, after meal. The dosage may be adjusted according to the diseases, age or symptoms. Strictly follow the instructions of your doctor/pharmacist.
  • Take a dose as soon as possible when you remembered that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking the medicine without the instructions of your doctor.

Precautions while taking this medicine

  • There is a possibility of temporal fertility in women who take nonsteroidal antiinflammatory drug for a long period. Consult with your doctor/pharmacist if you desire pregnancy.

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: gastric discomfort, gastric pain, nausea, diarrhea, loss of appetite, abdominal pain, epigastric pain, dyspepsia, rash, itching, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • facial pallor/flop sweat, breathing difficulty, hives [shock, anaphylactoid symptoms]
  • fever, dry cough, breathing difficulty  [interstitial pneumonia]
  • fever, redness/sores of the mucous membrane, erythema  [Stevens-Johnson syndrome, toxic epidermal necrosis]
  • generalized fatigability, nausea, yellowness in the skin or conjunctiva [liver dysfunction, jaundice]
  • decrease of urine output, swelling, thirst  [nephrotic syndrome, renal failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.