くすりのしおり

Internal
Revised: 4/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Lendormin D Tablets 0.25mg
 Active ingredient:
Brotizolam
 Dosage form:
white tablet, diameter: 8.0 mm, thickness: 2.7 mm
 Print on wrapping:
(Face) Lendormin D, レンドルミンD 0.25mg, 13C
(Back) レンドルミンD 0.25mg, 睡眠導入剤, 口腔内崩壊錠, company logo, Boehringer Ingelheim, recycle mark

Effects of this medicine

This medicine inhibits the hypothalamus and cerebral limbic system controlling emotion through GABA, a typical inhibitory transmitter of central nervous system. As a result, unnecessary stimulation from the autonomic nervous system and other sites is blocked, demonstrating central nervous action including hypnosis, sedation and anti-anxiety.
It is usually used to treat insomnia and for anesthetic premedication.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: glaucoma, myasthenia gravis (muscle weakness) or diminished respiratory function due to cor pulmonale, pulmonary emphysema, bronchial asthma or cerebrovascular disorder.
    If you are in a debilitated state.
    If you have: heart, liver or renal disorder or organic brain disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Insomnia: In general, for adults, take 1 tablet (0.25 mg of the active ingredient) at a time, once a day, right before bedtime.
    Preanesthetic: In general, for adults, take 1 tablet (0.25 mg of the active ingredient) at a time, once a day, on the night before surgery, and 2 tablets (0.5 mg) at a time, for anesthetic premedication.
    The dosage may be adjusted according to the disease, age or symptoms. Strictly follow the instructions.
  • If you temporarily wake up during sleeping and work, etc. after taking this medicine for insomnia, you may have no recollection of what happened during that time. Do not take this medicine if you are going to wake up and work.
  • You may moisten the tablet with saliva on your tongue, then crush it lightly with the tongue, and take it without water. Do not take the tablet without water when you are lying down.
  • If you miss a dose and have a long time before getting up in the next morning, take the missed dose as soon as possible. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so. Especially if you suddenly decrease the dosage or stop your medication, adverse reactions such as insomnia and anxiety may occur.

Precautions while taking this medicine

  • Avoid drinking alcohol with this medicine since it may intensify the sedative effect of this medicine.
  • Avoid operating dangerous machinery, such as driving a car. The effects of this medicine may carry over to the next morning and afterwards causing drowsiness, diminished attention or concentration and decreased reflex movements.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include residual sleepiness/drowsiness, light headedness, dull headache, dull, dizziness, headache, malaise, unrest, excitement, rash and erythema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • general dullness, loss of appetite, yellowing of the skin and the white of eyes [liver dysfunction, jaundice]
  • temporary loss of memory after taking this medicine, hazy feeling in the head [transient anterograde amnesia, twilight state]
  • unable to stop taking this medicine, insomnia (due to dose reduction or discontinuation), anxiety [dependence]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from light, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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