くすりのしおり

Internal
Revised: 7/2014

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Nitorol R Capsules 20mg
 Active ingredient:
Isosorbide dinitrate
 Dosage form:
white capsule, length 14.0mm
 Print on wrapping:
(Face) ニトロールR20mg, NR20E
(Back) NR20E, NitorolR, 20mg, ニトロールR

Effects of this medicine

This medicine dilates the venous and peripheral vascular systems to reduce the work load of the heart and dilates the coronary arteries to increase the oxygen supply to the heart, alleviating oxygen shortage in the heart. It prevents the occurrence of the symptoms such as feeling of tightness in the chest or sharp chest pain due to cardiac ischemia.
It is usually used for treatment of ischemic heart disease such as angina or myocardial infarction, however, the medicine is not to use for prompt relief of an angina attack which has suddenly developed.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reaction(itch, rash, etc.) to any medicine.
    If you have hypotension, cardiogenic shock, glaucoma, anemia, head trauma, brain hemorrhage, pulmonary hypertension, cardiomyopathy or hepatic dysfunction.
    If you are taking sildenafil citrate (Viagra, Revatio), vardenafil hydrochloride hydrate (Levitra), tadalafil (Cialis, Zalutia, Adcirca) or riociguat (Adempas).
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take one capsule (20 mg as the active ingredient) twice a day, to be adjusted depending on the disease, symptom severity or age. Strictly follow the instructions.
  • Take the capsule without any chewing. Because if you take the crushed capsule by chewing, the blood concentration of isosorbide dinitrate increases more than enough transiently, as may cause a headache more likely.
  • If you miss a dose, take a dose as soon as possible if you remember that you missed a dose 6 hours or over before the next dose. If it is 6 hours or less before the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause attention deficit or loss of concentration/reflexes. Avoid operating a motor vehicle or machinery.
  • Use caution when consuming alcoholic beverages, since consuming too much alcohol while on this medication may cause headache, dizziness or dizziness on standing up.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, headache, dizziness, palpitation, flush, vomiting and upper abdominal pain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep this medicine out of the reach of children and away from direct sunlight, heat or moisture.
  • If you have leftover medicines, dispose of them appropriately and do not keep any unused medicine.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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