くすりのしおり

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Revised: 9/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ADEFURONIC ZUPO 12.5
 Active ingredient:
Diclofenac sodium
 Dosage form:
white to pale yellow suppository, length: approx. 24 mm
 Print on wrapping:

Effects of this medicine

This medicine suppresses synthesis of prostaglandin which is considered as a cause of inflammation/pain/fever. It consequently shows analgetic/anti-inflammatory/antipyretic actions.
It is usually used for relief of pain/inflammation associated with rheumatoid arthritis, osteoarthritis, low back pain, post-birth pain or post-surgery, of for urgent relief of fever in acute upper respiratory tract inflammation.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have peptic ulcer, hematological abnormality, liver disorder, renal disorder, hypertension, cardiac function failure, proctitis, rectal bleeding, hemorrhoid, aspirin-induced asthma or its history, encephalitis/encephalopathy due to influenza.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For adults: In general, insert 2 to 4 suppositories (25 to 50 mg of active ingredient) into the rectum at a time, once or twice a day. It is advisable to be used at the lowest dose possible, depending on the age and symptoms. For elderly patients, start with low doses in order to prevent shock due to low body temperature.
    For children: In general, insert 0.5 to 1.0 mg of the active ingredient per kilogram of the body weight into the rectum at a time, once or twice a day. It is advisable to be used at the lowest dose possible, depending on the age and symptoms. Start with low doses in order to prevent shock due to low body temperature. The approximate single dose for each age are 6.25 mg for 1 to under 3 years old, 6.25 to 12.5 mg for 3 to under 6 years old, 12.5 mg for 6 to under 9 years old and 12.5 to 25 mg for 9 to under 12 years old.
    This preparation contains 12.5 mg of the active ingredient in a piece. Strictly follow the instructions.
  • Particularly follow the dosage instructions of your doctor if patient is infant, elderly, or in severely exhausted state.
  • Please use it as much as possible after defecation.
  • If you miss a dose, use a dose as soon as possible. If it is almost time for the next dose (less than 5 hours if you use twice a day), skip the missed dose. You should not use two doses at one time.
  • If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop using this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause sleepiness/dizziness/foggy vision. Avoid operating dangerous machinery, such as driving a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea/vomiting, abdominal pain, diarrhea, loose stool, irritation at the insertion site, constipation, rash, dizziness and edema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, cold sweat, hives [shock, anaphylaxis]
  • facial pallor, cold sweat, severe abdominal pain, melena (black stool) [gastrointestinal ulcer accompanied by hemorrhagic shock or intestinal perforation, gastrointestinal stenosis/obstruction]
  • fever, sore throat, nasal/gum bleeding [aplastic anemia, hemolytic anemia, agranulocytosis, decreased platelets]
  • fever, redness in a wide area of skin, bloodshot eyes or lip erosion [toxic epidermal necrolysis, mucocutaneous ocular syndrome, erythroderma]
  • decreased urine output, edema, headache [acute renal disorder, nephrosis syndrome]
  • cough, respiratory distress, wheezing (whistling breath) [severe asthma attack (aspirin-induced asthma)]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store in a cold place (refrigerator, etc.).
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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