くすりのしおり

Internal
Published: 9/2009

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
UFT E combination granule T150 [Conventional therapy]
 Active ingredient:
Tegafur
Uracil
 Dosage form:
white to yellowish white granules
 Print on wrapping:
ユーエフティE配合顆粒T150 150 mg/0.75 g, TC438

Effects of this medicine

This medicine enhances antitumor effects by combining tegafur and uracil. Tegafur is converted into fluorouracil, which attacks cancer cells, and uracil suppresses the degradation of fluorouracil. This therapy is expected to relieve symptoms through reduction in the size of cancer (tumor).
It is usually used to improve subjective and objective symptoms of head and neck cancer, stomach cancer, colorectal cancer, liver cancer, gallbladder/biliary cancer, pancreatic cancer, lung cancer, breast cancer, bladder cancer, prostate cancer and cervical cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have bone marrow suppression (decrease in white blood cell count, etc.), diarrhea, infections, renal disorder, gastrointestinal ulcer/bleeding, diabetes mellitus or varicella (chickenpox).
    If you have or have a history of liver disorder or heart disease.
    If you are currently receiving radiotherapy.
    If you have been treated with anti-cancer medicines before.
    If you are taking TS-1 (a fluoropyrimidine) or have taken this combined medicine within the last 7 days.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1.5 to 3 g (300 to 600 mg as tegafur) in 2 to 3 divided doses a day. Also, take 3 g (600 mg as tegafur) in 2 to 3 divided doses a day for cervical cancer. Strictly follow the instructions.
  • You should never take this medicine with TS-1 (a fluoropyrimidine). You should also not take this medicine if you have stopped taking TS-1 within the last 7 days.
  • If you miss a dose, follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • During the treatment, laboratory tests (blood, liver and renal function tests) are performed regularly to detect asymptomatic adverse reactions. Be sure to keep your visiting schedule.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include loss of appetite, nausea, vomiting, diarrhea and pigmentation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • bleeding tendency, general malaise, sore throat, fever  [bone marrow suppression]
  • yellow discoloration of the skin, general malaise, yellow discoloration of the white of eyes, loss of appetite [serious liver disorder]
  • diarrhea, severe abdominal pain [serious enterocolitis]
  • light headedness, forgetfulness, speaking difficulty [psychoneurotic disorder including leukoencephalopathy]
  • difficult to smell [anosmia]
  • breathing difficulty, fever, dry cough  [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask your pharmacy on how to discard the remainder.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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