くすりのしおり

Injection
Revised: 4/2016

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Yondelis I.V. infusion 0.25mg
 Active ingredient:
Trabectedin
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine shows an antitumor effect by binding with DNA in cancer cells and thus suppressing their proliferation.
It is usually used to treat malignant soft-tissue tumor.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, this medicine is administered by intravenous drip infusion over the period of 24 hours at a time. It is then discontinued for at least 20 days. This dosing schedule should be repeated as 1 cycle. Ask your doctor about the specific dosing schedule.

Precautions while taking this medicine

  • Avoid taking any food containing St. John's wort (a kind of herb) with the medicine because the effect of the medicine may be affected.
  • Use an effective contraceptive method to prevent pregnancy because this medicine may possibly affect the fetus.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea, loss of appetite, general malaise, constipation, vomiting and anemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • yellowing of the skin and the white of eyes, general malaise, loss of appetite [liver failure, hepatic dysfunction]
  • bleeding tendency, prolonged bleeding, anemia [bone-marrow depression]
  • fever, chill, cold-like symptoms [infection]
  • muscle pain, lassitude, reddish brown urine [rhabdomyolysis]
  • sudden breathing difficulty, chest pain, decreased blood pressure, fast pulse or slow pulse, hot flush in face, edema, sweating [serious hypersensitivity]
  • shortness of breath, cough, breathing difficulty, general edema [cardiac dysfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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