くすりのしおり

Injection
Published: 8/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
DARBEPOETIN ALFA INJECTION 10mcg SYRINGE [KKF]
 Active ingredient:
Darbepoetin alfa (genetical recombination)
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine acts on cells that grow into red blood cells (RBCs) to increase the number of RBCs and consequently improves anemia attributable to renal diseases.
It is usually used in the treatment of renal anemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have a history of myocardial infarction, pulmonary infarction or cerebral infarction.
    If you have hypertension.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For hemodialysis patients: In general, for adults and children, inject intravenously once per week or once every two weeks.
    For patients with chronic kidney disease not on dialysis and peritoneal dialysis patients: In general, for adults and children, inject subcutaneously or intravenously once every two or four weeks.
    In any case, ask your doctor about the dosing instructions.
  • This medicine will be administered over a long period under observation of the efficacy.
  • If this medicine is used for the first time or used after an interval, a lower dose may be administered intravenously or subcutaneously to observe whether any abnormalities occur.

Precautions while taking this medicine

  • Take iron to acquire adequate efficacy. If iron preparation is prescribed, take as instructed by your doctor.
  • This medicine may cause hyperkalemia. Follow adequate dietary control.
  • If you are a patient with chronic kidney disease not on dialysis, seek direction for optimal water intake from your doctor or pharmacist and follow their instruction.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include increased blood pressure, shunt thrombosis/occlusion, headache and malaise. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • paralysis on one side, decreased consciousness, difficulty speaking [cerebral infarction]
  • decreased consciousness, headache, nausea [cerebral bleeding]
  • general malaise, yellowing of the white of eyes, loss of appetite  [liver dysfunction]
  • yellowing of the white of eyes, yellowing of the skin, brown urine [jaundice]
  • dizziness, sudden severe headache, numbness of limbs [hypertensive encephalopathy]
  • cold sweat, dizziness, decreased consciousness [shock]
  • swollen eye and lip, palpitations, hives [anaphylaxis]
  • general malaise, dizziness, shortness of breath [pure red-cell aplasia]
  • breathing difficulty, sudden pressurized feeling in chest, cold sweat [myocardial infarction]
  • phlegm with blood, chest pain, breathing difficulty [pulmonary infarction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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