くすりのしおり

Injection
Published: 3/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
METHYLENE BLUE INTRAVENOUS INJECTION 50mg "DAIICHI SANKYO"
 Active ingredient:
Methylthioninium chloride hydrate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine (methylene blue) is reduced to leucomethylene blue under the presence of reductase in red blood cells to reduce methemoglobin to hemoglobin, thereby improving methemoglobinemia.
It is usually used to treat toxic methemoglobinemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: glucose-6-phosphate dehydrogenase deficiency, NADPH reductase deficiency, methemoglobinemia with chlorate, methemoglobinemia due to nitrite used as antidote for cyanide poisoning, renal dysfunction, methemoglobinemia with aniline or diaphenylsulfone.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject this medicine intravenously.
    If symptoms do not improve within 1 hour after injection, repeat injection as needed.

Precautions while taking this medicine

  • Due to the use of this medicine, blood oxygen saturation may show an apparently low value in measurement of it by pulse oximeter.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include confusion, hives, abdominal pain, nausea, chest pain, breathing difficulty, urination difficulty, mydriasis, local tissue necrosis at the injection site, and fever. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • pale face, cold sweat, dizziness on standing up, dizziness, shortness of breath, loss of consciousness [shock, anaphylaxis]
  • skin and mucous membrane turning blueish purple to dark purple, headache, breathing difficulty, red-brown urine [progression of methemoglobinemia, hemolytic anemia]
  • decreased urine output, edema, general malaise [renal failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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