くすりのしおり

Injection
Revised: 2/2016

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Halaven injection 1mg
 Active ingredient:
Eribulin Mesilate
 Dosage form:
Injection
 Print on wrapping:

Effects of this medicine

This medicine induces apoptotic cell death by stopping cancer cell division and thus exerts an inhibitory effect on tumor proliferation.
It is usually used to treat unresectable or recurrent breast cancer and malignant soft-tissue tumor.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you have decreased bone marrow function (fever, subcutaneous bleeding).
    If you have decreased liver function.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject this medicine intravenously once a day, once a week for two consecutive weeks.
    For the third week, injection is discontinued. This is counted as one cycle and should be repeated.
  • Adverse reactions and therapeutic effects depend on patient's condition. Ask your doctor about the treatment span.

Precautions while taking this medicine

  • Decreased bone marrow function may lead you to susceptibility to infection or bleeding tendency.
    However, you may not easily notice it by yourself.
    Therefore, blood test may be conducted periodically (once to twice a week or more frequently).

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hair loss, fatigue, decreased appetite, nausea, stomatitis, taste abnormality, fever, peripheral neuropathy, vomiting, headache, diarrhea, malaise, rash, muscle pain, constipation, anemia, nasopharyngitis, upper respiratory infection and liver dysfunction. If any of these symptoms occur, consult with your doctor or pharmacis
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • general malaise and feverish more than usual, subcutaneous bleeding [bone marrow suppression]
  • chills, sudden high fever with shivering, fast heart rate, cough and sputum, shortness of breath [infection (sepsis, pneumonia,etc.) ]
  • numbness/pain of limbs, hypoesthesia [peripheral neuropathy]
  • general malaise, nausea, loss of appetite, yellowing of the body and the white of eyes  [liver dysfunction]
  • fever, dry cough, breathing difficulty [interstitial pneumonia]
  • fever, general malaise, red dotted rash on skin [muco-cutaneo-ocular syndrome, erythema multiforme]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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