くすりのしおり

Internal
Revised: 3/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ADEFURONIC TABLETS 25mg
 Active ingredient:
Diclofenac sodium
 Dosage form:
yellow tablet, diameter: 7.1 mm, thickness: 3.9 mm
 Print on wrapping:
(face) アデフロニック 25mg, t 126, 25mg, (back) ADEFURONIC 25mg, アデフロニック25mg,防湿保存

Effects of this medicine

This medicine suppresses synthesis of prostaglandin, which is considered as a cause of inflammation/pain/fever. It consequently shows analgesic/anti-inflammatory/antipyretic actions.
It is usually used for relief of pain/inflammation associated with rheumatoid arthritis, osteoarthritis, low back pain, post-surgery or tooth extraction, or for relief of fever/pain in acute upper respiratory tract inflammation.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have peptic ulcer, hematological abnormality, hepatic disorder, renal disorder, hypertension, cardiac function failure, aspirin-induced asthma or its history, encephalitis/encephalopathy due to influenza.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For pain/inflammation associated with rheumatoid arthritis, osteoarthritis, low back pain, post-surgery or tooth extraction: In general, for adults, take 3 to 4 tablets (75 to 100 mg of the active ingredients) a day in 3 divided doses. If you take the medicine on an as-needed basis, take 1 to 2 tablets (25 to 50 mg) at a time.
    For fever/pain caused by acute upper respiratory tract inflammation: In general, for adults, take 1 to 2 tablets (25 to 50mg of the active ingredients) at a time, as needed. The dosage may be adjusted according to your age and symptoms. However, up to twice a day, and the maximum daily dose is 4 tablets (100 mg).
    In any case, avoid taking the medicine on an empty stomach. Strictly follow the instructions.
  • If the medicine stays and disintegrates in esophagus, it may cause esophageal ulcer. Take it with a large amount of water and pay extra attention when taking right before bedtime.
  • If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose (less than 4 hours if you take in 3 divided doses), skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • If you experience drowsiness, dizziness, or blurred vision, avoid operating dangerous machinery such as driving a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include loss of appetite, nausea/vomiting, stomachache, abdominal pain, diarrhea, stomatitis, rash and edema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, cold sweat, hives [shock, anaphylaxis]
  • facial pallor, cold sweat, severe abdominal pain, melena (black stool) [gastrointestinal ulcer accompanied by hemorrhagic shock or intestinal perforation, gastrointestinal stenosis/obstruction]
  • fever, sore throat, nasal/gum bleeding [aplastic anemia, hemolytic anemia, agranulocytosis, decreased platelets]
  • fever, redness in a wide area of skin, bloodshot eyes and lip erosion [toxic epidermal necrosis, mucocutaneous ocular syndrome, erythroderma]
  • cough, respiratory distress, wheezing (whistling breath) [severe asthmatic attack (aspirin-induced asthma)]
  • headache, fever, vomiting [aseptic meningitis]
  • muscle pain, lassitude, reddish brown urine [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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