くすりのしおり

Internal
Revised: 5/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
TAKELDA Combination Tablets
 Active ingredient:
Aspirin
Lansoprazole
 Dosage form:
white to yellowish white tablet with redbrown to dark-brown flecks, diameter: 10.0 mm, thickness: 5.4 mm
 Print on wrapping:
(face) タケルダ, 水でお飲みください (back) タケルダ, アスピリン・ランソプラゾール配合

Effects of this medicine

Aspirin inhibits activities of platelet cyclooxygenase-1 to suppress platelet aggregation and eventually delay or prevent blood coagulation while lansoprazole inhibits the enzymatic activity of proton pump in the gastric mucosa to suppress gastric acid secretion.
Aspirin prevents obstruction of a blood vessel by a blood clot that has formed but may cause gastric or duodenal ulcers; therefore, lansoprazole prevents such untoward events.
It is usually used to suppress thrombus/embolus formation due to angina pectoris, myocardial infarction, or ischemic cerebrovascular disorder or to suppress thrombus/embolus formation after coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) in patients with a history of gastric or duodenal ulcers.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have peptic ulcer, hematological disorder or its history, bleeding tendency or its predisposition, bronchial asthma or its history, liver disorder or its history, renal disorder or its history.
    If you drink alcohol on a regular basis.
    If you are scheduled for surgery, cardiac catheter test or tooth extraction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet at a time, once a day. Strictly follow the instructions.
  • This medicine cannot be dissolved in the mouth. Take the medicine with water without chewing or breaking it into pieces.
  • If you miss a dose, take the missed dose as soon as possible. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may induce or enhance gastrointestinal bleeding; therefore, avoid taking this medicine with any alcoholic beverage.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include constipation, diarrhea, hives, rash, itching, erythema multiforme, edema, anemia, platelet hypofunction (prolonged bleeding time), enlarged feeling of abdomen, stomatitis, nausea, colitis, headache, dizziness, excitement, conjunctivitis, gynecomastia, malaise, over breathing, and hypoglycemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • generalized rash, facial edema, breathing difficuly [anaphylaxis, shock]
  • dullness, fever, shortness of breath, nasal/subcutaneous bleeding, red-brown urine [pancytopenia, agarnulocytosis, aplastic anemia, granulocytopenia, hemolytic anemia, decreased platelet count, anemia]
  • yellowing of the skin and the white of eyes, dullness, loss of appetite [serious liver dysfunction]
  • fever, general malaise, eruptions on/reddening of the skin and eyes and eruptions/reddening in the mouth, exfoliation of skin [toxic epidermal necrolysis, mucocutaneous-ocular syndrome, exfoliative dermatitis]
  • fever, dry cough, breathing difficuly [interstitial pneumonia]
  • fever, skin eruption, joint pain [interstitial nephritis]
  • headache, nausea/vomiting, consciousness disorder, motor paralysis, bloody phlegm, bloody stool, nose bleeding, vision disorder [intracranial/pulmonary/gastrointestinal/nose/ocular fundus bleeding]
  • breathing difficuly, whistling sound [asthmatic attack]
  • heartburn, heavy feeling of stomach, back pain, abdominal pain, diarrhea, bloody stool [peptic ulcer, small/large intestine ulcer]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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