くすりのしおり

Injection
Published: 4/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ZERBAXA Combination for Intravenous Drip Infusion
 Active ingredient:
Tazobactam sodium
Ceftolozane sulfate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine is an antibiotic which exerts bactericidal activity through binding to bacterial penicillin-binding protein, resulting in inhibition of bacterial cell wall synthesis. In addition, some bacteria produce enzymes that degrade antibiotics (beta-lactamases), while this medicine also contains an ingredient which inhibits beta-lactamase.
It is usually used to treat cystitis, pyelonephritis, peritonitis, intra-abdominal abscess, cholecystitis and liver abscess, caused by Streptococcus, Escherichia coli, Citrobacter, Klebsiella, Enterobacter, Proteus and Pseudomonas aeruginosa, susceptible to this medicine.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you have renal dysfunction.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, this medicine is given by intravenous drip infusion over 60 minutes 3 times a day.
  • For peritonitis, intra-abdominal abscess, cholecystitis, and/or liver abscess, this medicine should be used in conjunction with metronidazole injection.
  • Ask the doctor about the treatment span.
  • Lie/sit quietly from the beginning to the end of drip infusion.

Precautions while taking this medicine

  • This medicine is excreted mainly through the kidneys. Before and during use of this medicine, regular renal function tests are performed, to determine the optimal dose.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, nausea and headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, asthmatic attack, itch [shock, anaphylaxis]
  • abdominal pain, frequent diarrhea [Clostridium difficile colitis]
  • decreased urine volume, edema, general malaise [acute renal disorder]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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