くすりのしおり

Internal
Published: 1/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
BENECID Tablets 250mg
 Active ingredient:
Probenecid
 Dosage form:
white to pale yellowish white tablet, diameter: 10.1mm
 Print on wrapping:
BENECID Tab.250mg, ベネシッド錠250mg, KC16, 250mg

Effects of this medicine

This medicine inhibits the reabsorption of uric acid in the renal tubule and excretes uric acid in the blood into the urine.
It also inhibits excretion in renal tubules such as penicillin and maintains these high blood concentrations.
It is usually used to treat gout, to maintain penicillin and para-aminosalicylic acid concentration in the blood.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines and had blood abnormality, kidney stone and renal disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Gout: In general, for adults, take 2 to 8 tablets (0.5 to 2 g of the active ingredient) a day, in 2 to 4 divided doses. Then take 4 to 8 tablets (1 to 2 g) a day, in 2 to 4 divided doses as a maintenance dose.
    To maintain blood concentration of peniciline and para-amino salicylic acid:
    In general, for adults, take 1 to 2 tablets (0.25 to 0.5g of the active ingredient) at a time, 4 times a day. The dosage should be adjusted according to the age or symptoms. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • In case of gout, follow the instructions of your doctor and take as much fluid as possible in order to increase your urinary volume and avoid urinary stones or symptoms.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include loss of appetite, stomach discomfort, dermatitis, anemia, fever and itching. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemic symptoms (dizziness, pale face), fever, bleeding tendency [hemolytic anemia, aplastic anemia]
  • respiratory distress, hives, malaise [anaphylactoid symptoms]
  • loss of appetite, nausea, yellow discoloration of skin and/or conjunctiva [hepatic necrosis]
  • decreased urine output, edema of the whole body, malaise [nephrotic syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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