くすりのしおり

Internal
Revised: 8/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
PARKISTON Combination Tablets L250
 Active ingredient:
Levodopa
Carbidopa hydrate
 Dosage form:
oval, light red tablet, major axis: approx. 13.6 mm, minor axis: approx. 6.8 mm, thickness: approx. 5.5 mm
 Print on wrapping:
パーキストン配合錠L250,PARKISTON Combination tab. L250

Effects of this medicine

This medicine is a combination preparation of levodopa and carbidopa. Levodopa is taken up into the brain and changes into dopamine to supplement insufficient dopamine, and consequently improves Parkinson's disease. Carbidopa enhances the transfer of levodopa into the brain. The medicine takes effect on akinesia/hypokinesia, muscle rigidity and tremor associated with Parkinson's disease and parkinsonian syndrome, and improves body movements in daily life. It also improves other accompanying symptoms.
It is usually used for the treatment of Parkinson's disease and parkinsonian syndrome.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have closed angle glaucoma.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For patients who have never taken levodopa before: In general, for adults, the initial dose is started at 100 to 125 mg of levodopa at a time, 100 to 300 mg daily, and the dose is increased by 100 to 125 mg every day or every other day, then the optimal dose is determined as the maintenance dose (standard dose is 200 to 250 mg of levodopa at a time, 3 times daily). The dosage may be adjusted according to the symptoms, however, the daily dose should not exceed 1,500 mg.
    For patients who have been taking levodopa: In general, for adults, take at least 8-hour interval after taking levodopa alone, the initial dose is determined based on equivalent to one fifth of levodopa of the daily maintenance dose, and take it in 3 divided doses daily. After that, the dosage may be adjusted according to the symptoms, and the optimal dose is determined as the maintenance dose (standard dose is 200 to 250 mg of levodopa at a time, 3 times daily). The daily dose should not exceed 1,500 mg.
    This preparation contains 250 mg of levodopa in a tablet. Strictly follow the instructions.
  • If you miss a dose, take a dose as soon as possible when you remember that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • The medicine may cause sudden sleep; unconsciousness; decline of attention, concentration or reflection. Avoid driving a car or operating dangerous machinery after taking the medicine.
  • Consult your doctor if your sweat, urine or saliva turns black while you are receiving the treatment with the medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea, loss of appetite, vomiting, dyskinesia (tremor, continuous involuntary movements of tongue or jaw), orthostatic hypotension (orthostatic dizziness), rash and anemia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • high fever, muscle rigidity, tremor or convulsion of the limbs [Syndrome malin]
  • loss of sense of place or time, seeing things or hearing sounds that do not exist, general malaise [confusion, hallucination, depression]
  • epigastric pain, tenderness in the upper abdomen, vomiting [deterioration of gastric or duodenal ulcer]
  • light headedness, yellowing of the skin/the white of eyes, fatigability [hemolytic anemia, thrombopenia]
  • sudden drowsiness [sudden sleep]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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