くすりのしおり

Internal
Published: 10/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
BACTRAMIN Combination Tablet
 Active ingredient:
Trimethoprim
Sulfamethoxazole
 Dosage form:
white tablet, diameter: approx. 11mm, thickness: approx. 5.3mm
 Print on wrapping:
バクトラミン配合錠

Effects of this medicine

This medicine contains 2 kinds of active ingredients working on folate which is necessary for bacteria; one is for blocking folate biosynthesis and another is for blocking folate activation. Consequently, it has antibacterial effect synergistically.
It is usually used to treat general infections such as pneumonia, secondary infection caused by chronic respiratory lesion, complicated cystitis, pyelonephritis, infectious enteritis, typhoid, or paratyphoid. It is also usually used to treat pneumocystis pneumonia and to suppress symptom onset.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: glucose-6-phosphate dehydrogenase deficiency, hepatic/renal disorder, folate deprivation or folate metabolism abnormality (a history of gastric resection, just after delivery, congenital folate metabolism abnormality).
    If you have/had blood disease.
    If you or any of your parents or siblings have previously experienced any allergic reactions such as bronchial asthma, rash, and hives.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General infections: In general, for adults, take 2 tablets at a time, twice a day. It should be adjusted according to your age and symptoms.
    Treatment of pneumocystis pneumonia: In general, for adults, take 9 to 12 tablets in 3 to 4 divided doses a day. In general, for children, take 15 to 20 mg/kg of trimethoprim in 3 to 4 divided doses a day. The dosage should be adjusted according to your age and symptoms in any case.
    Suppression of symptom onset of pneumocystis pneumonia: In general, for adults, take 1 to 2 tablets at a time, once a day. In general, for children, take 2 to 4 mg/kg of trimethoprim at a time, twice a day.
    Each tablet contains 80 mg of trimethoprim and 400 mg of sulfamethoxazole as the active ingredients. Strictly follow the instructions in any case.
  • If you miss a dose, take a dose as soon as possible. However, if it is almost time for the next dose, take a dose as soon as possible and skip the next dose. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Contact your doctor immediately when you notice that you are having such symptoms as anemia, bleeding tendency (nose bleeding, etc.), continuous bleeding, persistent bruise, rash, hives, blister and itch.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include loss of appetite, nausea, stomach discomfort, rash, hives, erythema, bulla, pruritus and hematologic disorder (anemia, bleeding tendency). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • palpitation, shortness of breath, bruise, dizziness [aplastic anemia, hemolytic anemia, anemia megaloblastic, methemoglobinemia, pancytopenia, agranulocytosis, thrombocytopenia]
  • subcutaneous bleeding, bruise, yellowness in the skin and/or the white of the eye, dark urine [thrombotic thrombocytopenic purpura, hemolytic uremic syndrome]
  • breathing difficulty, cold sweat [anaphylaxis, shock]
  • lip/intraoral sore, red spots and breakable blisters (bullas) all over the body [toxic epidermal necrolysis, oculomucocutaneous syndrome]
  • numbness in the limbs, lassitude, muscle pain, red-brown urine [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store at room temperature (1 to 30 degrees Celsius), away from light and moisture.
  • Discard the remainder. Do not store them.Ask the pharmacist or healthcare facility how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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