くすりのしおり

Injection
Published: 8/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
IMFINZI Injection 120mg
 Active ingredient:
Durvalumab (Genetical Recombination)
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine inhibits the binding of PD-1, a receptor on T cells (immune cells), to PD-L1, substances expressed on cancer cells, thereby enhancing T cell activation and suppressing tumor growth.
It is usually used to treat unresectable, locally advanced non-small-cell lung cancer as maintenance therapy after definitive chemoradiation therapy.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have autoimmune disorder or its history.
    If you have interstitial lung disease (including radiation pneumonitis) or its history.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, administer by intravenous infusion over 60 minutes once every 2 weeks.
  • The maximum duration of treatment is 12 months.
  • Ask the doctor about the treatment span.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, hypothyroidism, diarrhea and interstitial lung disease. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • fever, dry cough, breathing difficulty, shortness of breath [interstitial lung disease (including radiation pneumonitis)]
  • fever, nausea, vomiting, abdominal pain, diarrhea [colitis]
  • sweating, nausea, severe abdominal pain, watery stool, muddy stool [severe diarrhea]
  • general malaise, edema, intolerance to coldness, slow in conversation or in motion [hypothyroidism]
  • tendency to sweat, decreased body weight, bulging eyes, swollen thyroid, palpitation, tremor in hands, insomnia [hyperthroidism]
  • general malaise, decreased consciousness, impaired mind, vomiting, nausea, loss of appetite, hypotension, impaired judgment [adrenal dysfunction]
  • fatigability, thirst, excessive fluid intake, increased urine output, general malaise, absent-mindedness and loss of consciousness, impaired mind, loss of appetite, impaired judgment, decreased blood pressure, absence of menstruation, decreased breast milk, decreased sexual desire, decreased body temperature, dry skin [pituitarism]
  • general malaise, decreased body weight, thirst, excessive fluid intake, increased urine output, decreased consciousness, impaired mind, deep large breathing, tremor in limbs, impaired judgment [type 1 diabetes mellitus]
  • general malaise, yellowing of the white of eyes, nausea, vomiting, loss of appetite, itching, yellowing of the skin, dark colored urine [liver dysfunction, hepatitis]
  • joint pain, fever, headache, swollen feeling, bloody urine, facial edema [renal disorder]
  • lassitude, fever, difficulty swallowing, breathing difficulty, rash, muscle pain [myositis]
  • lassitude, numbness of hands, stiffness in limbs, numbness of feet, muscle pain, reddish brown urine [rhabdomyolysis]
  • respiratory distress, consciousness disorder, swelling of eyelids/lips/tongue, fever, chills, vomiting, cough, dizziness, palpitation [infusion reaction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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