くすりのしおり

Internal
Published: 4/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ATOZET Combination Tablets HD
 Active ingredient:
Ezetimibe/Atorvastatin calcium hydrate
 Dosage form:
white oval tablet, major axis: 14.5 mm, minor axis: 5.8 mm, thickness: 4.5 mm
 Print on wrapping:
(Face) アトーゼット配合錠HD, 333
(Back) ATOZET HD, アトーゼット配合錠HD

Effects of this medicine

This medicine inhabits absorption of cholesterol and vegetal sterol through protein in small intestinal cells, and also prevents production of cholesterol in the liver. It consequently lowers the cholesterol levels in the blood.
It is usually used to treat hypercholesterolemia, and familial hypercholesterolemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have liver or renal disorder.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet at a time, once daily, after meal. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible within your bedtime. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Strictly follow the instructions on dietary/ exercise therapy.
  • Avoid taking grapefruit juice together with this medicine, since it may enhance the therapeutic effects of this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include abdominal bloating, constipation, and gastritis. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • muscle pain, stiffness in limbs, reddish brown urine [rhabdomyolysis, myopathy, immune-mediated necrotizing myopathy]
  • nausea/vomiting, general malaise, yellowing of the skin or whites of the eyes [hepatitis fulminant, hepatitis, hepatic function disorder, jaundice]
  • throat pain, palpitation/shortness of breath, bleeding of nose/gums, subcutaneous bleeding [agranulocytosis, pancytopenia, thrombocytopenia]
  • fever, loss of appetite, red rash [toxic epidermal necrolysis, oculomucocutaneous syndrome, erythema multiforme]
  • thirst, excessive urination, general malaise [hyperglycemia, diabetes mellitus]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from light, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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