くすりのしおり

Internal
Published: 10/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Aciclovir Granules 40% "Nichiiko"
 Active ingredient:
Aciclovir
 Dosage form:
white to faintly yellowish white glanules
 Print on wrapping:
(0.5g分包)NICHI-IKO, アシクロビル顆粒40%「日医工」, 0.5g, (アシクロビル 200mg含有)
(2g分包)NICHI-IKO, アシクロビル顆粒40%「日医工」, 2g, (アシクロビル 800mg含有)

Effects of this medicine

This medicine is an antiviral agent. It inhibits the DNA synthesis of virus to suppress the growth of herpes simplex/varicella/herpes zoster virus.
It is usually used to treat herpes simplex, suppression of herpesvirus infection (herpes simplex) caused by hematopoietic stem cell transplantation, herpes zoster and suppression of recurrence of genital herpes.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • [Adults]
    Herpes simplex : In general, for adults, take 0.5 g (200 mg of the active ingredient) at a time, 5 times a day.
    Onset suppression of herpesvirus infection (herpes simplex) caused by hematopoietic stem cell transplantation : In general, for adults, take 0.5 g (200 mg of the active ingredient) at a time, 5 times a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation throughout.
    Herpes zoster : In general, for adults, take 2.0 g (800 mg of the active ingredient) at a time, 5 times a day.
    [Children]
    Herpes simplex : In general, for children, take 0.05 g per kg of body weight (g/kg) (20 mg of the active ingredient ) at a time, 4 times a day. The maximum single dose is 0.5 g (200 mg) at a time.
    Onset suppression of herpesvirus infection (herpes simplex) caused by hematopoietic stem cell transplantation : In general, for children, take 0.05 g/kg (20 mg of the active ingredient ) at a time, 4 times a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation throughout. The maximum single dose is 0.5g (200 mg) at a time.
    Herpes zoster : In general, for children, take 0.05 g/kg (20 mg of the active ingredient ) at a time, 4 times a day. The maximum single dose is 2.0 g (800 mg) at a time.
    Varicella : In general, for children, take 0.05 g/kg (20 mg of the active ingredient ) at a time, 4 times a day. The maximum single dose is 2.0 g (800 mg) at a time.
    Recurrence suppression of genital herpes : In general, for children, take take 0.05 g/kg (20 mg of the active ingredient ) at a time, 4 times a day. The maximum single dose is 0.5g (200 mg) at a time.
    The dosage may be adjusted according to age and symptoms of the patient in any case. Strictly follow the instructions.
  • If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Please take a larger amount of water than usual. However, if you have been instructed fluid restriction, please consult with your doctor or pharmacist.
  • This medicine may cause consciousness disorder, etc. Pay close attention to operate in potentially hazardous activities such as driving a car. Especially, patient with renal dysfunction may cause consciousness disorder easily. Avoid operating in potentially hazardous activities, if you are instructed to refrain it.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include anemia, diarrhea, abdominal pain, fever, rash, blister, erythema, hives, itch, fixed drug eruption and photosensitivity. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, angioedema, hives [anaphylactoid shock, anaphylaxis]
  • high fever, general malaise, hematuria, subcutaneous bleeding in limbs [pancytopenia, agranulocytosis, thrombocytopenia, disseminated intravascular coagulation, thrombocytopenic purpura]
  • decreased urine output, edema of limbs and face, general malaise [acute renal failure]
  • consciousness disorder (coma), hallucination, convulsion [neuropsychiatric symptom]
  • high fever, bloodshot eyes, erythema  [toxic epidermal necrolysis, mucocutaneous-ocular syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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