くすりのしおり

Injection
Published: 6/2014

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ZOLEDRONIC ACID I.V. INFUSION 4mg /5mL "NIPRO"[bone lesion]
 Active ingredient:
Zoledronic acid hydrate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine relieves bone pain or prevents bone fracture associated with bone metastasis of solid tumors or multiple myeloma.
It is usually used to treat bone lesion associated with multiple myeloma and bone metastasis of solid tumors.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have renal dysfunction.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject by intravenous infusion once every 3 to 4 weeks over 15 minutes.
  • It may be administered for a long time depending on your response to the treatment.
  • Ask your doctor about your frequency of injection.

Precautions while taking this medicine

  • To prevent hypocalcemia, you may take calcium or vitamin D according to your doctor instructions.
  • Maintain your oral hygiene and receive your dental checkup regularly while injecting this medicine.
  • If you are receiving tooth extraction or dental implant, inform your dentist or oral surgeon that you are receiving this medicine treatment.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include erythematous skin rash (red rash), macular skin rash (red rash), angioneurotic edema (swelling of eyelid/lip, breathing difficulty), hives, erythema, blister, skin rash, eczema, itch, pain, arthralgia, skeletal pain, muscle pain, back pain, influenza-like symptoms, fever, malaise, fatigue, chill, arthritis and arthrocele. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • decrease of urine output, swelling, fever [acute renal failure, interstitial nephritis]
  • general edema, respiratory distress, easy to breathe in sitting position than when lying  [congestive heart failure (edema, respiratory distress, pulmonary edema)]
  • convulsion, numbness/ tremoring limbs, unable to recognize place, time or name [hypocalcemia]
  • fever, cough, respiratory distress  [interstitial pneumonia]
  • paint of jaw, swelling of the gum tissues, tooth mobility [osteonecrosis and osteomyelitis of the jaw]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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