くすりのしおり

Internal
Published: 6/2009

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
AMANTADINE HYDROCHLORIDE TABLETS 50mg "ZE" [central nervous system agent]
 Active ingredient:
Amantadine hydrochloride
 Dosage form:
pale yellow tablet, diameter: 7.1 mm, thickness: 3.7 mm
 Print on wrapping:
(Face) アマンタジン塩酸塩50mg「ZE」, ZE, 50mg, (Back) Amantadine Hydrochloride50mg, アマンタジン塩酸塩50mg

Effects of this medicine

This medicine relieves the symptoms of Parkinson's syndrome (tremor of limbs, etc.) by enhancing the activity of dopaminergic neurons in the brain. It also improves brain function (mental activity) by working as dopamine agonist (dopamine, noradrenalin, serotonin).
It is usually used to improve decreased motivation/initiative occurring as aftereffects of cerebral infarction and to treat Parkinson's syndrome.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have epilepsy or a history of it, convulsive predisposition or renal disorder needing dialysis.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For Parkinson's syndrome: In general, for adults, start with 2 tablets (100 mg of the active ingredient) a day in 1 or 2 divided doses, and after 1 week take 2 tablets (100 mg) at a time, twice a day as the maintenance dose. The dosage may be adjusted according to the age or symptoms, but the maximum daily dose is 2 tablets (100 mg) at a time, three times a day.
    For aftereffects of cerebral infarction: In general, for adults, take 2 tablets (100 mg of the active ingredient) a day in 2 to 3 divided doses. The dosage may be adjusted according to the age or symptoms, but in elderly or patients with renal disorder, the maximum dose should not exceed 2 tablets (100 mg) a day.
    In any case, strictly follow the instructions.
  • If you miss a dose, take a dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • The medicine may cause dizziness, light-headedness, dizziness on standing up and blurred vision. Pay attention to performing dangerous machinery such as working at heights or driving a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include sleep disorder, drowsiness, anxiety, hyperthymic, agitation, incoordination, excitement, dizziness, headache/dull headache, lassitude /malaise, sweating, livedo reticularis, edema of lower limbs, chest pain, hypothermia and urinary incontinence. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • high fever, disturbed consciousness, muscle rigidity [neuroleptic malignant syndrome]
  • fever, bloodshot eyes, erythema/blister in extensive skin [mucocutaneous ocular syndrome, toxic epidermal necrosis]
  • decreased vision, foreign body sensation in eyes, sensitive to light [diffuse superficial keratitis, corneal edema-like symptoms]
  • general edema, breathing difficulty, easy breathing in upright position [heart failure]
  • faint consciousness, hallucination/delusion, convulsion [disturbed consciousness (including coma), psychological symptoms, convulsion, myoclonus]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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