くすりのしおり

Internal
Revised: 2/2012

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
WARFARIN Potassium Tablets 1mg "TOWA"
 Active ingredient:
Warfarin potassium
 Dosage form:
white tablet with split line, diameter : 8.0 mm, thickness : 2.7 mm
 Print on wrapping:
Tw532, ワルファリンK1mg「トーワ」, 1mg

Effects of this medicine

This medicine suppresses the action of vitamin K which inhibits blood from coagulating and prevents blood clots from forming.
It is usually used to treat and prevent thromboembolism (venous thrombosis, myocardial infarction, pulmonary embolism, cerebral embolism, slowly progressive cerebral thrombosis, etc.).

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are taking capecitabine (Xeloda).
    If you are bleeding or prone to bleeding.
    If you have liver disorder/renal disorder, malignant tumor, hyperthyroidism or hypothyroidism.
    If you have just had a surgery or suffered an external injury.
    If you have just delivered a baby or had a miscarriage.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • The daily dose and dose frequency will be determined by your doctor according to results of blood coagulation tests, etc. In general, for adults, take 1 to 5 tablets (1 to 5 mg of the active ingredient) at a time, once a day as the initial dose. Continue at this dosage for several days, and the maintenance dose will be determined after the effects are confirmed by tests. From this point onward, take the maintenance dose once a day while receiving tests on a regular basis. The maintenance dose for adults is often around 1 to 5 tablets (1 to 5 mg) at a time. The dosage for children will also be determined by their doctors according to results of blood coagulation tests, etc. The standard maintenance dose is 0.16 mg/kg/day for infants under 12 months old and 0.04 to 0.10 mg/kg/day for children 1 year old or over but under 15 years old. Strictly follow the instructions.
  • If you miss a dose, take the missed dose when you remember. However, if more than half a day has passed from the scheduled time, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Do not take any food or drink containing a large amount of vitamin K such as natto (fermented soybeans), chlorella, aojiru (green juice), and St. John's wort, as they may diminish medicinal effects.
  • Refrain from drinking alcohol while taking this medicine, as alcohol may diminish or intensify medicinal effects.
  • Avoid work or exercise that may increase the risk of injury, as bleeding will not stop easily while taking this medicine.
  • Consult with your doctor regularly and receive blood coagulation tests. If you are going to undergo surgery or tooth extraction, consult with your doctor beforehand. When you visit another medical facility, tell the doctor, dentist or pharmacist in the facility that you are taking this medicine.
  • Pay attention not to get pregnant while taking this medicine, as it may cause harmful effects on the fetus. If you want to become pregnant, consult with your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, erythema, hives, dermatitis, fever and loss of hair. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • headache/chest pain/abdominal pain, black stool/bloody stool/bloody urine, nose bleeding/gum bleeding/subcutaneous bleeding [bleeding inside organs such as brain bleeding, mucosal bleeding, subcutaneous bleeding]
  • flat red rash with pain, punctate bleeding, hemorrhagic blister [skin necrosis]
  • general malaise, loss of appetite, yellow discoloration of the skin and the white of eyes [liver dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from light, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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