くすりのしおり

Injection
Revised: 5/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
KYPROLIS for Intravenous Injection 40mg
 Active ingredient:
Carfilzomib
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine inhibits chymotrypsin-like activity of proteasome to suppress the growth of cancer cells.
It is usually used to treat relapsed or refractory multiple myeloma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have heart disorder or have a history of it.
    If you have liver disorder.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In combination with lenalidomide and dexamethasone: In general, for adults, inject by intravenous infusion once a day on Days 1, 2, 8, 9, 15 and 16, followed by a drug cessation period of 12 days. This 28-day period is counted as 1 treatment cycle and repeat this cycle 12 times. From Cycle 13, inject by intravenous infusion once a day on Days 1, 2, 15 and 16 with a drug cessation period of 12 days.
    In combination with dexamethasone: In general, for adults, inject by intravenous infusion once a day on Days 1, 2, 8, 9, 15 and 16, followed by a drug cessation period of 12 days. This 28-day period is counted as 1 treatment cycle and repeat this cycle.
  • Ask your doctor about your treatment span.

Precautions while taking this medicine

  • If you or your partner have a possibility of pregnancy, avoid pregnancy while you are taking this medicine and for a certain period of time after you discontinue this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hyperglycemia (dry mouth, excessive urination, general malaise), rash, constipation, muscular spasm, fever, peripheral neuropathy (numbness of hands/feet, feeling cold), nausea, hypertension, diarrhea, pneumonia, upper respiratory inflammation, taste abnormality, erythema, anemia, fatigue, insomnia, respiratory infection, asthenia and respiratory distress. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • palpitation, shortness of breath, edema, chest pain [heart disorder]
  • fever, dry cough, respiratory distress [interstitial lung disease]
  • respiratory distress, chest pain [pulmonary hypertension]
  • general malaise, loss of appetite, yellowing of the skin and the white of eyes [hepatic failure, hepatic dysfunction]
  • decreased urine output, edema, headache [acute renal failure]
  • decreased consciousness, decreased urine output, shortness of breath [tumor lysis syndrome]
  • fever, bleeding tendency, fatigability, shortness of breath [myelosuppression]
  • fever, joint pain, facial flush, vomiting, shortness of breath, syncope [infusion reaction]
  • bleeding tendency, nasal bleeding, gum bleeding, purpura, bloody urine [thrombotic microangiopathy]
  • convulsion, headache, consciousness disorder, visual disorder [reversible posterior leukoencephalopathy syndrome, encephalopathy]
  • headache, dull headache, dizziness, shoulder stiffness [hypertension, high blood pressure crisis]
  • edema, heat sensation, topical pain [venous thromboembolism]
  • sudden headache, consciousness disorder, motor paralysis, abdominal pain, vomiting of blood., black stool [bleeding]
  • cold-like symptoms, general malaise, fever, vomiting [infection]
  • nausea, vomiting, severe abdominal pain, vomiting of blood, melena [perforation of the digestive tract]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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