くすりのしおり

Injection
Published: 9/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ADRIACIN Injection 50
 Active ingredient:
Doxorubicin hydrochloride
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine suppresses cancer cell proliferation by forming a complex with cancer cell DNA and inhibiting DNA and RNA synthetase reactions.
It is usually used to improve symptoms of malignant lymphoma, lung cancer, gastrointestinal cancer, breast cancer, bladder tumor or bone sarcoma. It is also used concomitantly with other anti-malignant tumor medicine to treat breast cancer (pre/postoperative chemotherapy in operable patients), uterine body cancer (postoperative chemotherapy, chemotherapy for metastasis/recurrence), malignant tumor of bone/soft tissue, malignant bone tumor, multiple myeloma, childhood malignant solid tumor, urothelial cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have cardiac dysfunction or a history of it.
    If you have myelosuppression, liver disorder, renal disorder, infection and chickenpox.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, inject this medicine intravenously once a day and then discontinue temporarily. This dosing schedule is repeated. For bladder tumor, inject this medicine intravesically once a day. In any case, duration of administration may vary by other concomitant medicine and condition of the patient. Ask your doctor about your dosing schedule.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include alopecia, nausea, vomiting, loss of appetite, stomatitis, anaemia, bladder irritation, fever, contracted bladder, feeling of residual urine, tachycardia, arrhythmia and chest pain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • edema, chest pain, general malaise [myocardial disorder, heart failure]
  • nasal bleeding, general malaise, fever [myelosuppression such as pancytopenia, anaemia, leukopenia, neutropenia, thrombocytopenia and bleeding]
  • cold sweat, dizziness, impaired consciousness [shock]
  • dry cough, shortness of breath, fever [interstitial pneumonia]
  • urine leakage, frequent urination [contracted bladder]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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