くすりのしおり

Internal
Revised: 4/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
OLANZAPINE Tablets 2.5mg "SAWAI"
 Active ingredient:
Olanzapine
 Dosage form:
white tablet, diameter: 7.2 mm, thickness: 3.3 mm
 Print on wrapping:
オランザピン2.5mg「サワイ」, Olanzapine2.5mg「SAWAI」

Effects of this medicine

This medicine improves symptoms such as hallucination/delusion, as well as strong anxiety and irritation, and stabilizes mood by acting on various receptors (dopamine, serotonin, etc.) in the brain. This medicine also improves manic symptoms such as uncontrollable excitation and behavior and depressive symptoms such as depressed mood in bipolar disorder.
It is usually used to treat schizophrenia, improve manic symptoms and depressive symptoms in bipolar disorder and treat gastrointestinal symptoms (nausea, vomiting) associated with chemotherapy medicine for cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have or have a history of diabetes mellitus.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For schizophrenia: In general, for adults, start with 2 to 4 tablets (5 to 10 mg of the active ingredient) at a time, once a day. Take 4 tablets (10 mg) once a day as the maintenance dose. The dosage may be adjusted according to the age or symptoms, but the maximum daily dose is 8 tablets (20 mg).
    For improvement of manic symptoms in bipolar disorder: In general, for adults, start with 4 tablets (10 mg of the active ingredient) at a time, once a day. The dosage may be adjusted according to the age or symptoms, but the maximum daily dose is 8 tablets (20 mg).
    For improvement of depressive symptoms in bipolar disorder: In general, for adults, start with 2 tablets (5 mg of the active ingredient) at a time, once a day, and then, the dosage will be increased to 4 tablets (10 mg) once a day. In any case, take the dosage before bedtime. The dosage may be adjusted according to the age or symptoms, but the maximum daily dose is 8 tablets (20 mg).
    For gastrointestinal symptoms (nausea and vomiting) associated with chemotherapy medicine for cancer: In general, for adults, take 2 tablets (5 mg of the active ingredient) at a time, once a day in combination with other antiemetics. The dosage may be increased according to your condition, but the maximum daily dose is 4 tablets (10 mg).
    In any case, strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Patients in a depressive state with bipolar disorder may show behavioral changes such as suicidal ideation/aggression due to the nature of this disease. Therefore, you and your family members should keep close contact with your doctor.
  • This medicine may cause increased body weight. Pay attention to your diet and exercise and be careful not to gain too much weight.
  • Pay attention that this medicine may cause dizziness or dizziness on standing up for a while after the initiation of this medicine.
  • This medicine may cause somnolence (absent-mindedness) or decreased attention/concentration/reflex movement. Avoid working at heights or operating dangerous machinery, such as driving a car.
  • Alcohol (drinking) may intensify medicinal effects. Refrain from drinking alcohol while taking this medicine.
  • Smoking may diminish medicinal effects. Refrain from smoking while taking this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include excitement, somnolence, insomnia, anxiety, dizziness/light headedness, akathisia (unable to keep still), tremor (shivering of limbs), constipation, excessive appetite, dry mouth, rash, itch, facial edema, hives, small papule, photosensitivity, angioedema, increased body weight and malaise. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • dry mouth, excessive fluid intake, excessive urination, frequent urination [hyperglycemia, diabetic ketoacidosis, diabetic coma]
  • lassitude, malaise, cold sweat [hypoglycemia]
  • remaining motionless, muscle stiffness, sweating [malignant syndrome]
  • general malaise, loss of appetite, yellow discoloration of the skin and the white of eyes [liver dysfunction, jaundice]
  • convulsive muscle contraction [convulsion]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask your pharmacy or medical institution on how to discard the remainder.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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