くすりのしおり

Internal
Published: 6/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
LYRICA OD Tablets 150mg
 Active ingredient:
Pregabalin
 Dosage form:
white tablet, diameter: 10.5 mm, thickness: 6.0 mm
 Print on wrapping:
リリカ OD 150mg, LYRICA OD 150mg, PTLY150

Effects of this medicine

This medicine inhibits calcium influx and suppresses release of excitatory neurotransmitters such as glutamic acid in the central nervous system to tranquilize over-excited nerves and relieve pain.
It is usually used to treat neuropathic pain and pain associated with fibromyalgia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: renal dysfunction, congestive heart failure or a history of angioedema.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Neuropathic pain: In general, for adults, as an initial dose, take 75 mg of the active ingredient at a time, twice a day, and then the daily dosage is gradually increased up to 300 mg in a week or more. The dosage may be adjusted according to the age or symptoms. However, the maximum daily dosage is 600 mg in two divided doses.
  • Pain associated with fibromyalgia: In general, for adults, as an initial dose, take 75 mg of the active ingredient at a time, twice a day. The daily dosage is gradually increased up to 300 mg in a week or more and will be maintained at 300 to 450 mg. The dosage may be adjusted according to the age or symptoms. However, the maximum daily dosage is 450 mg in two divided doses.
    This preparation contains 150 mg of the active ingredient in a tablet. In any case, strictly follow the instructions.
  • You can take the medicine without water. Moisten the tablet with saliva on your tongue and crush it lightly with your tongue, then swallow it with saliva.
    You can also take it with a glass of water or lukewarm water like regular tablets.
  • If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause dizziness, somnolence or loss of consciousness and there is a case resulted in car accident. Avoid performing dangerous operations such as driving a car while taking this medicine. Especially, if you are an elderly adult, close attention should be payed because there is a case resulted in falling and fracture due to these symptoms.
  • This medicine may cause weight gain. Consult with your doctor or pharmacist if a sign of obesity occurs.
  • This medicine may cause double vision and blurred vision. Consult with your doctor or pharmacist if any of them occurs.
  • Pay attention that alcohol may intensify medicinal or medical effects.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include dizziness, somnolence, edema and weight gain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • light headedness, state close to sleep with impaired consciousness, loss of consciousness [dizziness, somnolence, unconsciousness]
  • respiratory distress, general edema, palpitation upon exertion [heart failure, pulmonary edema]
  • muscle pain, lassitude, reddish brown urine [rhabdomyolysis]
  • decreased urine output, edema of the limbs/face, malaise [renal failure]
  • swelling of the face/tongue/lips/throat, hives, respiratory distress [angioedema, shock, anaphylaxis]
  • lassitude, malaise, cold sweat [hypoglycaemia]
  • dry cough, respiratory distress, fever [interstitial pneumonia]
  • high fever, bloodshot eyes, red rash [Stevens-Johnson syndrome, erythema multiforme]
  • loss of appetite/nausea/vomiting, general malaise, jaundice, itch [fulminant hepatitis, liver disfunction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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