くすりのしおり

Injection
Revised: 8/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
XIAFLEX lnj.
 Active ingredient:
Collagenase(clostridium histolyticum)
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine disrupts collagen in the cord at the injection site to improve finger flexion contracture.
It is usually used to treat Dupuytren's contracture.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, this medicine is injected in 3 divided points of the cord which is the cause finger joint Dupuytren's contracture. If its effect is insufficient, this medicine may be injected to the same cord additionally at an interval of 1 month for up to 3 doses.
  • Administration of a local anesthetic agent prior to injection of this medicine is not performed. This is to prevent incorrect injection to the tendon/nerve other than to the aimed cord are overlooked by local anesthesia.
  • If the disease has resulted in multiple contractures and this medicine is injected to different cords, this medicine is injected at an interval of 1 month.

Precautions while taking this medicine

  • In principle, see your doctor the next day (approximately 24 hours) after injecting this medicine. If complete finger extension is not recognized at the time, a finger extension procedure may be performed.
  • After injecting this medicine, do not perform a finger extension procedure by yourself.
  • Wear a splint or perform finger flexion/extension exercises following the instructions of your doctor.
  • Do not bend/extend the treated (injected) finger until your doctor instructs you to do so.
  • This medicine may cause dizziness, headache or injection site pain/swelling. Pay attention when operating dangerous machinery such as driving a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include injection site pain/internal bleeding/swelling, contusion (damage to subcutaneous tissues and muscles due to excessive force applied to the affected part and around the affected part) and infectious symptoms [fever, chills, redness (the skin at the injection site becomes congested and reddened) or edema, etc.]. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, see your doctor immediately.
  • bending trouble/pain/swelling of injected finger joint [tendon rupture, ligament damage]
  • the skin is torn and scratched [skin laceration]
  • hives, breathing difficulty, reduction of blood pressure [anaphylaxis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

Keywords Search

 

 

 

 

Advanced Search

Browse by drug name A-Z
Browse by drug name A-Z