くすりのしおり

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ALLOPURINOL TABLETS 50mg "ZE"
 Active ingredient:
Allopurinol
 Dosage form:
white tablet, diameter: 6.5 mm, thickness: 2.2 mm
 Print on wrapping:
(face) ZE50, アロプリノール錠50mg「ZE」, 50mg
(back) ALLOPURINOL TABLETS 50mg「ZE」, アロプリノール錠50mg「ZE」

Effects of this medicine

This medicine suppresses uric acid production by inhibiting xanthine oxidase, resulting in decreased amount of uric acid in the blood and urine.
It is usually used to improve hyperuricemia in patients with gout or hypertension accompanied by hyperuricemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: hepatic disorder or have a history of it.
    If you have: renal function disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 4 to 6 tablets (200 to 300 mg of the active ingredient) a day, in 2 to 3 divided doses after meals. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions.
  • Gout attack (pain) may be temporarily intensified because of mobilization of urate when you start taking this medicine. However, do not change the dose or stop taking this medicine on your own unless your doctor instructs you to do so. If such a symptom occurs, consult with your doctor.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Drink plenty of fluids to increase urine output. However, if you have been instructed to restrict fluid intake, consult with your doctor or pharmacist.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, itch, joint pain, anemia, purpura, loss of appetite, gastric distress, loose stool, diarrhea, general malaise and depilation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • fever, rash, skin exfoliation [serious skin disorder such as toxic epidermal necrolysis, muco-cutaneo-ocular syndrome or dermatitis exfoliative, or hypersensitivity vasculitis]
  • rash, fever, swollen lymph nodes [drug-induced hypersensitivity syndrome]
  • cold sweat, pale face, respiratory distress [shock, anaphylaxis]
  • anemic symptoms, loss of appetite, sore throat [aplastic anemia, pancytopenia, agranulocytosis, decreased platelets]
  • general malaise, yellow discoloration of the skin and the white of eyes, loss of appetite [serious hepatic dysfunction such as hepatitis fulminant, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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