くすりのしおり

Internal
Published: 5/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
NINLARO capsules 2.3 mg
 Active ingredient:
Ixazomib citrate
 Dosage form:
faint red capsule, major axis: approx. 14.3 mm, minor axis: 5.3 mm
 Print on wrapping:
(Face)ニンラーロカプセル2.3mg, NINLARO capsules 2.3mg, 週1回 空腹時に1カプセル服用, (Back)NINLARO 2.3mg

Effects of this medicine

This medicine binds to proteasome, a complex of enzymes degrading proteins that become unnecessary in cells, and inhibits its chymotrypsin-like activity to suppress the growth of cancer cells.
It is usually used to treat recurrent or refractory multiple myeloma in combination with lenalidomide and dexamethasone.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have: liver disorder or renal disorder.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 4 mg of ixazomib at a time, once a week for 3 weeks (days 1, 8 and 15), on an empty stomach, and then stop taking this medicine for 13 days (days 16 to 28). This 4-week period is regarded as one course, which is repeated. However, the dosage may be decreased according to the condition. The dosage is decreased to 3 mg on the first step and 2.3 mg on the second step. This preparation contains 2.3 mg of ixazomib in a capsule. This medicine is taken with lenalidomide and dexamethasone. Strictly follow the instructions.
  • Avoid taking this medicine from 1 hour before meal to 2 hours after meal in order to avoid the influence of food.
  • Take the capsule with water without crushing, chewing or opening.
  • If you miss a dose and your next regularly scheduled dose is 3 days (72 hours) or longer away, take the missed dose as soon as possible. If you miss a dose and your next regularly scheduled dose is less than 3 days (72 hours) away, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • If you or your partner have a possibility of pregnancy, avoid pregnancy while you are taking this medicine and for a certain period after you discontinue this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include pneumonia, anaemia, taste abnormality, dizziness, peripheral neuropathy, cataract, nausea, diarrhea, vomit, constipation, indigestion, rash, itch, fatigue, insomnia, edema, convulsion, asthenia and decreased appetite. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, see your doctor immediately.
  • nose bleeding, gum bleeding, subcutaneous bleeding, prolonged bleeding [thrombocytopenia]
  • severe abdominal pain, watery stool, muddy stool [severe diarrhea]
  • fever, general malaise, rash on the skin or in the eyes/mouth [muco-cutaneo-ocular syndrome]
  • numbness of limbs, pain of limbs, paralysis [peripheral neuropathy]
  • convulsion, dizziness, headache, elevation of blood pressure, decreased consciousness, impaired mind, focus disorder [reversible posterior leukoencephalopathy syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

Keywords Search

 

 

 

 

Advanced Search

Browse by drug name A-Z
Browse by drug name A-Z