くすりのしおり

Internal
Revised: 6/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
UNISIA Combination Tablets LD
 Active ingredient:
Candesartan cilexetil
Amlodipine besilate
 Dosage form:
light yellow oval tablets, major axis 8.6 mm, minor axis 5.1 mm, thickness 3.0 mm
 Print on wrapping:
(Face) ユニシアLD 272, (Back) ユニシアLD

Effects of this medicine

This medicine lowers blood pressure by reducing peripheral vascular resistance via antagonism against receptor for the pressor substance angiotensin II as well as via its action upon the calcium channel in the vascular smooth muscle.
Usually, used for treatment of hypertension.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you have renal disorder, liver disorder, heart failure, hyperkalemia, or hyponatremia; are on hemodialysis, or on low-salt diet therapy; or in a preoperative state.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For adults, take 1 tablet at a time, once a day. Strictly follow the instructions of your doctor/pharmacist.
  • If you missed a dose, take the missed dose as soon as possible. If it is less than 8 hours to the next dose, skip the missed dose and then continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking the medicine without the instructions of your doctor.

Precautions while taking this medicine

  • As dizziness and light-headedness may appear due to excessive lowering of blood pressure, take extra care when working at heights or operating dangerous machinery such as driving a car.
  • Do not take the medicine together with grapefruits juice.

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: rash, itching, photosensitivity, angiitis, dizziness, light-headedness, dizziness on standing up, glow, fall in blood pressure, abdominal discomfort, enlarged feeling of the abdomen, diarrhea, cough, ear ringing, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • swelling of face, tongue and throat, breathlessness [angioedema]
  • feeling cold, vomiting, loss of consciousness [shock, syncope, loss of consciousness]
  • decreased urinary output, swelling of face and hands/feet, fever [acute renal failure]
  • numbness of hands/feet and lips, muscle weakness [hyperkalemia]
  • yellowing of the skin or whites of the eyes, dullness, loss of appetite [liver dysfunction, jaundice]
  • fever, sore throat, dullness [agranulocytosis, decreased white blood cell count]
  • lassitude, muscle pain, brown urine [rhabdomyolysis]
  • fever, dry cough, breathlessness [interstitial pneumonia]
  • cold sweat, feeling hungry, tremor in hands [hypoglycemia]
  • nose bleeding, gingival bleeding, subcutaneous bleeding [decreased platelet count]
  • bradycardia, dizziness [atrioventricular block]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and humidity.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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