くすりのしおり

Internal
Published: 6/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
IMATINIB TABLETS 200mg "TOWA"
 Active ingredient:
Imatinib mesilate
 Dosage form:
smoky yellowish red to deep yellowish red oblong tablet with split line, major axis: 16.0 mm, minor axis:7.4 mm,thickness: 4.7 mm
 Print on wrapping:
Tw545, イマチニブ200mg「トーワ」,200mg

Effects of this medicine

This medicine shows effect to suppress cancer cell proliferation by inhibiting abnormal action of tyrosine kinase (Bcr-Abl, KIT and FIP1L1-PDGFRα) which relates with cell proliferation.
It is usually used to treat chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Chronic myeloid leukemia: In general, for adults, take 2 tablets (400 mg of Imatinib) in chronic phase, or take 3 tablets (600 mg of Imatinib) in transition/acute phase, once a day after a meal. The dosage may be adjusted according to your blood test result, age or symptoms. The dose may be increased up to 3 tablets (600 mg) once a day in chronic phase, or 2 tablets (400 mg) twice a day in transition/acute phase, respectively.
    Philadelphia chromosome-positive acute lymphoblastic leukemia: In general, for adults, take 3 tablets (600 mg of Imatinib) once a day after a meal. The dosage may be reduced according to your blood test result, age or symptoms.
    Strictly follow the instructions in any case.
  • Take this medicine with a glass of water or lukewarm water (about 200 cc) after a meal.
  • If you miss a dose, do not take a dose immediately but skip the missed dose, and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Strictly follow the instructed inspection date. Check your body weight regularly. If you gain weight abnormally, consult with your doctor.
  • Avoid taking grapefruit juice with the medicine, since it may intensify medicinal effects.
  • Avoid taking any food containing St. John's wort, since it may diminish medicinal effects.
  • Pay attention when performing dangerous operations such as working at heights, driving a car or operating machinery since this medicine may cause dizziness, sleepiness, foggy vision etc.
  • If you have a possibility of being pregnant, make sure to avoid pregnancy during medication.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea/vomiting, diarrhea, loss of appetite, rash, superficial swelling (face, eyelid, lower limbs, etc.), dullness, muscle spasm and fever. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemic symptoms, fever, bleeding tendency [myelosuppression]
  • headache, consciousness disorder, paralysis of one side of body [cerebral hemorrhage, subdural hemorrhage]
  • melena/vomiting of blood, abdominal pain, abdominal bloating, anemia [gastrointestinal bleeding, gastric antral vascular ectasia, perforation of digestive tract, bleeding of tumor]
  • weight gain, chest pain, respiratory distress [serious fluid retention]
  • fever, dry cough, respiratory distress [interstitial pneumonia, pulmonary fibrosis]
  • facial pallor, respiratory distress, consciousness disorder [shock, anaphylaxis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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