くすりのしおり

Internal
Published: 5/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
VALACICLOVIR GRANULAR TABLETS 500mg MOCHIDA
 Active ingredient:
Valaciclovir hydrochloride
 Dosage form:
white to pale yellowish white, small size tablets in a sachet, diameter: approx. 3.2 mm, thick: approx. 3.3 mm
 Print on wrapping:
抗ウィルス化学療法剤, バラシクロビル粒状錠500mg「モチダ」, MO653

Effects of this medicine

This medicine suppresses the growth of herpes simplex/varicella/herpes zoster viruses.
It is usually used to treat herpes simplex, herpes zoster, chickenpox and as a prophylaxis of herpes simplex infection in patients with hematopoietic stem cell transplantation and recurrence of genital herpes.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have renal disease.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • [Adults]
    Herpes simplex: In general, for adults, take 1 sachet (500 mg of valaciclovir) at a time, twice a day.
    Suppression of onset of herpes virus infection (herpes simplex) associated with hematopoietic stem cell transplantation : In general, for adults, take 1 sachet (500 mg) at a time, twice a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation.
    Herpes zoster: In general, for adults, take 2 sachets (1,000 mg) at a time, 3 times a day.
    Chickenpox: In general, for adults, take 2 sachets (1,000 mg) at a time, 3 times a day.
    Suppression of recurrent genital herpes: In general, for adults, take 1 sachet (500 mg) at a time, once a day. The dosage or frequency of doses may be adjusted according to the symptoms.
    [Children]
    Herpes simplex: In general, for children who weigh 40kg or more, take 1 sachet (500 mg of valaciclovir) at a time, twice a day.
    Suppression of onset of herpes virus infection (herpes simplex) associated with hematopoietic stem cell transplantation : In general, for children who weigh 40kg or more, take 1 sachet (500 mg) at a time, twice a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation.
    Herpes zoster: In general, for children who weigh 40kg or more, take 2 sachets (1,000 mg) at a time, 3 times a day.
    Chickenpox: In general, for children who weigh 40kg or more, take 2 sachets (1,000 mg) at a time, 3 times a day.
    Suppression of recurrent genital herpes: In general, for children who weigh 40kg or more, take 1 sachet (500 mg) at a time, once a day. The dosage or frequency of doses may be adjusted according to the symptoms.
    In any case, the dosage or frequency of doses may be adjusted according to the underlying disease, strictly follow the instructions.
  • Do not put the medicine on the palm, take the medicine directly from the sachet.
  • When you open the sachet, cut side of the sachet up then open it gently (remove all the medicine out so as not to fly off from the sachet).
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should not take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Please take a larger amount of water than usual while you are on this medicine. However, if you have been instructed to restrict fluid intake, please consult with your doctor or pharmacist.
  • This medicine may cause reduced consciousness or decreased intelligent, take extra care when driving a car or operating dangerous machinery. Patients with renal dysfunction are more susceptible to consciousness disorder, so avoid operating dangerous machinery if instructed to do so by your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include headache, lowering of consciousness (sleepiness, etc), abdominal pain, nausea, diarrhea and hypersensitivity (rash, hives, itch and photosensitivity). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • breathing difficulty, angioedema (puffiness of eyelid or lip, etc), flare with general itch, palpitation [anaphylactic shock, anaphylaxis]
  • fever, bleeding tendency, general malaise  [blood disorder including pancytopenia/agranulocytosis]
  • decreased urine output, edema, headache [acute renal failure]
  • impaired consciousness, hallucination, convulsion [neuropsychiatric symptom]
  • fever, conjunctival hyperemia, mucosal eruption with pain in the oral mucosa [toxic epidermal necrolysis, oculomucocutaneous syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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