くすりのしおり

Injection
Revised: 3/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
CAMPTO 100mg for I.V.Infusion
 Active ingredient:
Irinotecan hydrochloride hydrate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine suppresses proliferation of cancer cells by inhibiting DNA synthesis of cancer cells.
It is usually used to treat inoperable/recurrent gastric cancer, inoperable/recurrent colorectal cancer, small cell lung cancer, non-small cell lung cancer, inoperable/recurrent breast cancer, cervical cancer, ovarian cancer, squamous cell cancer, malignant lymphoma (non-Hodgkin's lymphoma), malignant solid tumor of childhood and unresectable pancreatic cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have myelosuppression, infection, diarrhea (watery stool), intestinal paralysis, intestinal obstruction, interstitial pneumonia, pulmonary fibrosis, large quantities of ascitic/pleural fluid, jaundice, liver disorder, renal disorder, diabetic mellitus, severe generalized weakness or hereditary fructose intolerance.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For inoperable/recurrent gastric/colorectal cancer, cervical cancer, ovarian cancer: In general, administer by intravenous infusion once a day, 3 to 4 times at an interval of once every week as 1 course with a drug cessation period of at least 2 weeks and repeat the course. Otherwise, administer by intravenous infusion once a day, 2 to 3 times at an interval of once every 2 weeks as 1 course with a drug cessation period of at least 3 weeks and repeat the course.
    For small cell lung cancer, non-small cell lung cancer, inoperable/recurrent breast cancer, squamous cell cancer: In general, administer by intravenous infusion once a day, 3 to 4 times at an interval of once every week as 1 course with a drug cessation period of at least 2 weeks and repeat the course.
    For malignant lymphoma (non-Hodgkin's lymphoma): In general, administer by intravenous infusion once a day for 3 consecutive days, 2 to 3 times at an interval of once every week as 1 course with a drug cessation period of at least 2 weeks and repeat the course.
    For malignant solid tumor of childhood: In general, administer by intravenous infusion once a day for 5 consecutive days, 2 times at an interval of once every week as 1 course with a drug cessation period of at least 1 week and repeat the course.
    For unresectable pancreatic cancer: In general, administer by intravenous infusion once a day as 1 course with a drug cessation period of at least 2 weeks and repeat the course.
  • The treatment schedule differs depending on concomitant medicines and your conditions. The treatment span depends on the effect of this medicine after being used for a certain period of time. Ask your doctor for more detail.

Precautions while taking this medicine

  • The medicinal effect may be affected by some kinds of foods and drinks. Do not take grapefruit juice during treatment, since it may intensify the medicinal effect. Do not take any food containing St. John's wort during treatment, since it may weaken the medicinal effect.
  • If you have decreased bone-marrow function, infection or bleeding may occur. These symptoms are difficult to be detected by yourself. In order to find out symptoms as early as possible, periodic blood test is needed (1 to 2 times a week, or more frequently in some cases).

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include anemia, diarrhea, nausea, vomiting, loss of appetite, stomachache, intestinal inflammation, intestinal paralysis and loss of hair. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemic symptoms, fever, bleeding tendency [myelosuppression]
  • muddy/watery stool, stomachache, nausea [diarrhea, intestinal inflammation]
  • severe stomachache, nausea, melena [intestinal perforation, gastrointestinal bleeding, intestinal obstruction]
  • fever, dry cough, respiratory distress [interstitial pneumonia]
  • facial pallor, cold sweat, respiratory distress  [shock, anaphylaxis]
  • general malaise, loss of appetite, yellow discoloration of the skin and the conjunctiva [liver dysfunction, jaundice]
  • decreased urine output, edema, headache [acute renal disorder]
  • local pain such as chest/foot pain, tenderness, respiratory distress [thromboembolism]
  • paralysis of face/limbs on one side, headache, language disorder [cerebral infarction]
  • acute precordial pressure, anginal pain, cold sweat [myocardial infarction, angina attack]
  • abnormal cardiac contraction other than normal heartbeat, uncomfortable feeling in chest, palpitation [premature ventricular contraction]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Your risk of serious adverse reactions (especially decreased neutrophils) may be predicted by gene polymorphism diagnosis. For further information, consult with your doctor, pharmacist or nurse.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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