くすりのしおり

Internal
Revised: 6/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
VALACICLOVIR TABLETS 500mg "NP"
 Active ingredient:
Valaciclovir hydrochloride
 Dosage form:
white to faint yellowish white tablet, major axis: 18.5 mm, minor axis: 7.5 mm
 Print on wrapping:
(Face) バラシクロビル500mg「NP」, バラシクロビル, 500, (Back) VALACICLOVIR500mg「NP」, バラシクロビル500

Effects of this medicine

This medicine suppresses the growth of herpes simplex/varicella/herpes zoster viruses.
It is usually used to treat herpes simplex, herpes zoster, chickenpox, and to suppress onset of herpes simplex associated with hematopoietic stem cell transplantation, and to suppress recurrence of genital herpes.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • [Adults]
    Herpes simplex: In general, for adults, take 1 tablet (500 mg of valaciclovir) at a time, twice a day.
    Suppression of onset of herpes virus infection (herpes simplex) associated with hematopoietic stem cell transplantation : In general, for adults, take 1 tablet (500 mg of valaciclovir) at a time, twice a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation.
    Herpes zoster: In general, for adults, take 2 tablets (1,000 mg of valaciclovir) at a time, 3 times a day.
    Chickenpox: In general, for adults, take 2 tablets (1,000 mg of valaciclovir) at a time, 3 times a day.
    Recurrence suppression of genital herpes: In general, for adults, take 1 tablet (500 mg of valaciclovir) at a time, once a day.
    [Children]
    Herpes simplex: In general, for children weighing more than 40 kg, take 1 tablet (500 mg of valaciclovir) at a time, twice a day.
    Suppression of onset of herpes virus infection (herpes simplex) associated with hematopoietic stem cell transplantation : In general, for children weighing more than 40 kg, take 1 tablet (500 mg of valaciclovir) at a time, twice a day from 7 days prior to hematopoietic stem cell transplantation to 35 days after transplantation.
    Herpes zoster: In general, for children weighing more than 40 kg, take 2 tablets (1,000 mg of valaciclovir) at a time, 3 times a day.
    Chickenpox: In general, for children weighing more than 40 kg, take 2 tablets (1,000 mg of valaciclovir) at a time, 3 times a day.
    Recurrence suppression of genital herpes: In general, for children weighing more than 40 kg, take 1 tablet (500 mg of valaciclovir) at a time, once a day.
    In any case, the dosage and frequency of doses may be different according to the underlying disease or symptoms. Strictly follow the instructions.
  • Take the tablet without crushing because this medicine is coated tablet not to taste bitter in valaciclovir hydrochloride of the active ingredient. If it is difficult to take it, take one by one with a lot of water.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Please take a larger amount of water than usual while you are on this medicine. However, if you have been instructed to restrict fluid intake, please consult with your doctor or pharmacist.
  • This medicine may cause disturbance of consciousness, etc. Pay attention when you perform dangerous operations such as driving a car. Especially, patient with renal function disorder may cause dizziness and light-headed-feeling easily. Avoid operating machinery by your condition.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, hives, itch, photosensitivity, nausea, diarrhea, abdominal pain, dizziness, headache and reduced consciousness such as sleepiness. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • respiratory distress, angioedema [anaphylactic shock, anaphylaxis]
  • sore throat, headache, nose/gum/internal bleeding [pancytopenia, agranulocytosis, thrombocytopenia, disseminated intravascular coagulation, thrombocytopenic purpura]
  • decreased urine output, edema, headache [acute renal failure]
  • decreased consciousness, hallucination, convulsion [psychoneurotic symptom]
  • high fever, erythema/blister, conjunctival hyperemia [toxic epidermal necrolysis, mucocutaneous ocular syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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