くすりのしおり

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
AMANTADINE HYDROCHLORIDE TABLETS 100mg "ZE"
 Active ingredient:
Amantadine hydrochloride
 Dosage form:
pale yellow tablet, diameter 7.6 mm, thick 4.4 mm
 Print on wrapping:
(front) ZE63,アマンタジン塩酸塩100mg「ZE」,100mg
(back) Amantadine Hydrochloride 100mg,アマンタジン塩酸塩,100mg

Effects of this medicine

This medicine acts on neurotransmitter such as dopamine or serotonin in the brain, and improves decreased willingness and spontaneity as sequelae of cerebral infarction. It also relieves the symptoms of Parkinson's syndrome (tremor of limbs, etc.) by enhancing the activity of dopaminergic neurons in the brain. And it inhibits the process of influenza A virus entering the cells, and prevents viral multiplication.
It is usually used for improvement of decreased willingness and spontaneity resulting from sequelae of cerebral infarction, and to treat Parkinson's syndrome and influenza A infection.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you have epilepsy or a history of it, convulsive predisposition, renal disorder needing dialysis or liver disorder.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For treatment of sequelae of cerebral infarction: In general, for adults, take 100 to 150 mg of the active ingredient in 2 to 3 divided doses a day.
    For treatment of Parkinson's syndrome: In general, for adult, initially take 100 mg of the active ingredient in 1 to 2 divided doses a day. One week later, take 200 mg in 2 divided doses a day as the maintenance dose. The daily dose should not exceed 300 mg in 3 divided doses.
    For treatment of influenza A infection: In general, for adults, take 100 mg of the active ingredient in 1 to 2 divided doses a day. In elderly or patients with renal disorder, the daily dose should not exceed 100 mg.
    The dosage should be adjusted according to your disease, age and symptoms in either case. This preparation contains 100 mg of the active ingredient in a tablet. Strictly follow the instructions.
  • If you miss a dose, take a dose as soon as possible. However, if it is near the next dose (8 hours or less if your dosing schedule is once a day, 5 hours or less if your dosing schedule is twice a day), skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so. Sudden withdrawal may cause exacerbations of Parkinson's disease or high fever, etc.

Precautions while taking this medicine

  • The medicine may cause dizziness, light-headedness, dizziness on standing up and blurred vision. Avoid performing dangerous operations such as driving a car, operating machinery or working at heights.
  • It has been reported that psychoneurotic symptoms including abnormal behavior occurred after taking the medicine for influenza A infection, although its relationship to the medicine is unknown. If a child or minor patient is treated at home, the guardians should be careful not to leave them alone at least for 2 days.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include sleep disorder, dizziness, headache, excitement, constipation, loss of appetite, nausea, dry mouth, dizziness on standing up, rash and edema of lower limbs. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • high fever, disturbed consciousness, muscle stiffness [neuroleptic malignant syndrome]
  • fever, rash/blister in skin, bloodshot eyes [mucocutaneous ocular syndrome, toxic epidermal necrosis]
  • decreased vision, foreign body sensation in eyes, sensitive to light [diffuse superficial keratitis, corneal edema-like symptoms]
  • breathlessness, edema, easy breathing in upright position [heart failure]
  • faint consciousness, to see or hear something that is not really there, sudden muscle contraction [disturbed consciousness (including coma), psychological symptoms (hallucination etc.), convulsion, myoclonus]
  • muscle pain, lassitude, red-brown urine [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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