くすりのしおり

Internal
Published: 11/2010

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
GLIBENCLAMIDE TABLETS 1.25mg "TOWA"
 Active ingredient:
Glibenclamide
 Dosage form:
white tablet with split line, diameter: 6.0 mm, thickness: 1.9 mm
 Print on wrapping:
Tw534, グリベンクラミド「トーワ」, 1.25 mg

Effects of this medicine

This medicine stimulates pancreatic beta cells and promotes insulin secretion, resulting in decreased levels of blood glucose.
It is usually used to treat non-insulin-dependent diabetes mellitus (but only if dietary/exercise therapy alone is insufficient).

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have ketosis (hyperventilation, shivering of limbs), diabetic coma or precoma, insulin-dependent diabetes mellitus, liver or renal dysfunction, infections, external injury or gastrointestinal disorder such as diarrhea/vomiting.
    If you are in the pre-/post-operative period.
    If you are on bosentan hydrate.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, take 1 to 2 tablets (1.25 to 2.5 mg of the active ingredient), once a day, before or after breakfast, or in 2 divided doses a day, in the morning and evening, before or after meals. The dosage may be increased as necessary and the maintenance dose will be determined. However, the maximum daily dose will not exceed 8 tablets (10 mg). Strictly follow the instructions.
  • If you miss a dose, take the missed dose when you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Strictly follow the instructions on dietary/exercise therapy.
  • Hypoglycemic symptoms (such as lassitude, a strong sense of hunger, cold sweat and palpitation) may occur. Pay attention when working at heights or driving a car.
  • If hypoglycemic symptoms are noted without consciousness disorder, then in general, take sugar. If you are taking alpha-glucosidase inhibitors (acarbose, voglibose, miglitol) in combination with this medicine, take glucose. If you have decreased consciousness, contact your doctor immediately.
  • Consciousness disorder may occur as a hypoglycemic symptom. Inform your family and persons around you that you are taking this medicine.
  • Glucose in blood and urine needs to be tested on a regular basis. Be sure to follow your visiting schedule.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, photosensitivity and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • lassitude, a sense of hunger, sweating [hypoglycemia]
  • sore throat, fever, anemic symptoms (fatigability, general malaise, palpitation, etc.) [agranulocytosis, hemolytic anemia]
  • general malaise, yellow discoloration of the skin and the white of eyes, loss of appetite [hepatitis, liver dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask your pharmacy on how to discard the remainder.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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