くすりのしおり

Internal
Published: 3/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Ximency Combination Tablets
 Active ingredient:
Daclatasvir Hydrochloride
Asunaprevir
Beclabuvir Hydrochloride
 Dosage form:
pale green oval tablet, major axis: 15.3 mm, minor axis: 7.2 mm, thickness: 5.6 mm
 Print on wrapping:
(face) ジメンシー配合錠, BMS 224, (back) Ximency, ジメンシー配合錠, BMS 224

Effects of this medicine

This medicine inhibits multi-functional protein (NS5A), NS3/4A protease complex, and NS5B-RNA dependent RNA polymerase which are involved in hepatitis C virus replication. It shows suppressant action on the proliferation of hepatitis C virus (antiviral effects).
It is usually used to treat chronic hepatitis C and compensated cirrhosis type C.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have liver dysfunction or renal dysfunction.
    If you have hepatitis B virus infection or have a history of it.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 2 tablets at a time, twice a day after meals. Duration of medication is 12 weeks. Strictly follow the instructions.
  • If you missed a dose, and if you have more than 4 hours interval for the next dose, take the missed dose as soon as possible and continue your regular dosing schedule. If it is less than 4 hours interval for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Avoid taking any food containing St. John's wort, since it may decrease the blood level of the medicine and diminish medicinal effects.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include fever, headache, malaise and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • malaise, nausea, vomiting, itch, yellowing of the white of eyes/skin/urine [liver dysfunction, liver failure]
  • round or oval red rash, fever, joint pain [erythema multiforme]
  • bleeding tendency (nose bleeding, gum bleeding, subcutaneous bleeding), bruise [decreased platelet count]
  • fever, dry cough, respiratory distress [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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