くすりのしおり

Internal
Revised: 10/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
VONOPION Pack
 Active ingredient:
Vonoprazan fumarate
Amoxicillin hydrate
Metronidazole
 Dosage form:
1. Takecab Tablets 20mg: faint red elliptical tablet, major diameter: 11.2 mm, minor diameter: 6.2 mm, thickness: about 3.9 mm. 2. AMOLIN CAPSULES 250: capsule with white cap and white body, major diameter: 18.8 mm, minor diameter: 6.3mm. 3. Flagyl 250mg: white tablet, diameter: about 10.8 mm, thickness: about 6.0 mm.
 Print on wrapping:
(Face) ボノピオンパック, 1日2回(朝, 夕), 7日間続けて服用してください (Back) ボノピオンパックの服用方法

Effects of this medicine

Takecab Tablets 20mg inhibits gastric mucosal proton pump to suppress gastric acid secretion, thereby enhancing the effects of the antibacterial agent (AMOLIN CAPSULES 250 and Flagyl 250mg), while AMOLIN CAPSULES 250 and Flagyl demonstrate their antibacterial effects against Helicobacter pylori.
It is usually used to treat Helicobacter pylori infection of gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura or the stomach after endoscopic treatment of early-stage gastric cancer, and to treat Helicobacter pylori gastritis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have infectious mononucleosis, renal disorder, blood disorder (excl. idiopathic thrombocytopenic purpura), brain/spinal cord disorder or liver disorder.
    If you or any of your parents and siblings is predisposed to allergic symptoms such as bronchial asthma and rash.
    If you are in a poor oral feeding state.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet of Takecab Tablets 20mg (20 mg of vonoprazan), 1 tablet of Flagyl 250mg (250 mg of metronidazole) and 3 capsules of AMOLIN CAPSULES 250 (750 mg [titer] of amoxicillin hydrate) at a time, twice a day, for 7 days. This medicine is supplied in pack sheets. Each sheet contains one morning and one evening doses (good for one day) (each dose: 1 tablet of Takecab Tablets 20mg, 1 tablet of Flagyl 250mg and 3 capsules of AMOLIN CAPSULES 250). Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is less than 5 hours to the time for your next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Avoid alcohol drinking while taking this medicine. (Hangover symptoms such as abdominal pain, vomiting and facial flushing may occur.)

Possible adverse reactions to this medicine

These medicines may cause gastrointestinal symptoms such as diarrhea, taste abnormality or rash. Take the following measures according to symptoms.
1) In case of gastrointestinal symptoms such as loose stool and mild diarrhea or taste abnormality
Continue taking this medicine to complete the dosing schedule (7 days); do not reduce dosage or the number of medication at your discretion.
If symptoms become worsened, however, consult with your doctor or pharmacist.
2) In case of diarrhea associated with fever or abdominal pain, mucus- and/or blood-containing diarrhea or rash
Stop taking this medicine immediately and contact your doctor or pharmacist.
The most commonly reported other adverse reactions include stomach discomfort, abdominal enlarged feeling, constipation, nausea, fever, itchiness, edema, loss of appetite, stomatitis, heartburn, upper abdominal pain, oral aphthae, glossitis, black stool, depression, headache, dizziness, unstable feeling, eyestrain, fatigue and numbness. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • ill feeling, diaphoresis, breathing difficulty, rash, facial edema, convulsion [shock, anaphylaxis]
  • general malaise, fever, shortness of breath, nose bleeding/subcutaneous bleeding [pancytopenia, agranulocytosis, decreased granulocyte count, decreased white blood cell, decreased neutrophil count, decreased platelets]
  • yellowing of the skin and the white of eyes, general malaise, loss of appetite [liver dysfunction, jaundice]
  • fever, headache, arthralgia, rash/redness of the skin, eyes and oral cavity, tenseness/burning sensation/pain of the skin [toxic epidermal necrolysis, muco-cutaneo-ocular syndrome, acute generalized exanthematous pustulosis, erythema multiforme, erythroderma]
  • fever, dry cough, breathing difficulty [interstitial pneumonia, eosinophilic pneumonia]
  • decreased urine output, edema of the face and limbs, fever [acute renal disorder]
  • abdominal pain, frequent diarrhea, bloody stool [colitis pseudomembranous, hemorrhagic colitis]
  • numbness of limbs, pain, sensory paralysis [peripheral neuropathy]
  • convulsion, consciousness disorder, confusion [CNS (central nervous system) disorder]
  • nuchal rigidity, fever, headache, nausea/vomiting [meningitis aseptic]
  • abdominal pain, back pain, nausea/vomiting [acute pancreatitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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