くすりのしおり

Injection
Revised: 10/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
E Keppra for I.V. infusion 500mg
 Active ingredient:
Levetiracetam
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine controls epileptic seizures by suppressing excess excitation of brain nerves.
It is usually used to treat partial epileptic seizures or used with other antiepileptic drugs to treat generalized tonic-clonic seizures as an alternative when oral administration is temporarily not feasible.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have renal disorder or liver disorder.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • Switching from oral formulation:
    In general, this medicine should be equivalent to the frequency of the oral administration, infused intravenously over 15 minutes per dose.
  • Before using oral formulation:
    For adults: In general, this medicine infused intravenously over 15 minutes per dose twice a day.
    For children: In general, for children from 4 years of age, this medicine infused intravenously over 15 minutes per dose twice a day.
  • Once oral administration becomes feasible, this medicine should be immediately replaced with oral formulation.

Precautions while taking this medicine

  • This medicine may cause sleepiness, memory loss (forgetfulness), loss of concentration, diminished responsiveness, etc. Avoid performing dangerous operations such as driving a car.
  • Psychiatric symptom, such as change in mental or physical condition due to slight irritation, confusion, feeling irritated, easily excited and aggressive tendency, may occur and may lead to suicide attempt. If any of mental changes occur, check with your doctor or pharmacist.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nasopharyngitis, somnolence, headache, dizziness, diarrhea, constipation, upper respiratory infection, rash, injection site inflammation, injection site pain and injection site swelling. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • fever, erythema, general malaise [toxic epidermal necrolysis: TEN, Stevens-Johnson syndrome]
  • bleeding tendency, fever, sore throat [severe blood disorder (pancytopenia, agranulocytosis, leukocytopenia, neutropenia, thrombocytopenia)]
  • general malaise, loss of appetite, yellowness in skin or conjunctiva [hepatic failure, hepatitis]
  • severe upper abdominal pain, fever, nausea [pancreatitis]
  • change in mental or physical condition due to slight irritation, aggressive tendency, attempt suicide [aggression, suicide attempt]
  • muscle pain, lassitude, reddish brown urine [rhabdomyolysis]
  • decreased urine output, swelling, generalized fatigability [acute kidney injury ]
  • sudden fever, muscle stiffness, rapid pulse [neuroleptic malignant syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • [To family members] The patient and his/her families need to receive information about the possibility of developing symptoms, such as aggressive behaviors and suicidal thoughts, until you fully understand it. Keep close contact with your doctor. If you notice unusual behavior and symptoms, consult your doctor or pharmacist immediately.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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