くすりのしおり

Injection
Revised: 9/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ARRANON G Injection 250mg
 Active ingredient:
Nelarabine
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine is imported into proliferating cells which become malignant in the body to cause the death of these malignant cells.
It is usually used to treat T-cell acute lymphatic leukemia and T-cell lymphoblastic lymphoma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have received or are receiving any medication intrathecally.
    If you have received brain/spinal cord irradiation.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For adults: In general, intravenously inject the medicine over 2 hours, once a day on the 1st, 3rd, and 5th days followed by 16 days off.
    For children: In general, intravenously inject the medicine over 1 hour, once a day for 5 consecutive days followed by 16 days off.
    This 21-day cycle is considered 1 course. Repeat the course.
  • Ask your doctor about your treatment span.

Precautions while taking this medicine

  • This medicine may cause drowsiness. Pay close attention when driving a car or operating dangerous machinery.
  • If you or your partner have a possibility of pregnancy, avoid pregnancy while you are taking this medicine and for a certain period of time after you discontinue this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include anemia, fatigue, somnolence and nausea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, see your doctor immediately.
  • drowsiness, numbness of limbs, motor disorder [disorder of nervous system]
  • shortness of breath, dizziness, bleeding [blood disorder]
  • flank pain, bloody urine [tumor lysis syndrome]
  • muscle pain of limbs, numbness, lassitude [rhabdomyolysis]
  • general malaise, loss of appetite, yellowing of the skin and the mucosa [fulminant hepatitis, hepatic dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Administration of live vaccines to immunosuppressed patients may enhance/sustain vaccine-associated infections. Avoid administration of live vaccines during treatment with this medicine.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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