くすりのしおり

Internal
Revised: 9/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Rabefine PACK
 Active ingredient:
Pariet Tablets 10mg - Rabeprazole sodium
Sawacillin Tablets 250 - Amoxicillin hydrate
Flagyl Oral Tablets 250mg - Metronidazole
 Dosage form:
1. Pariet Tablets 10mg, pale yellow tablet, diameter 6.7 mm, thickness 3.6 mm; 2. Sawacillin Tablets 250, light orange tablet, diameter 10.0 mm, thickness 4.7 mm; 3. Flagyl Oral Tablets 250mg, white tablets, diameter 10.8 mm, thickness 6.0 mm
 Print on wrapping:
(front) ラベファインパック, 1日分(朝, 夕)
(back) ラベファインパックの服用方法

Effects of this medicine

Pariet Tablet 10mg suppresses gastric acid secretion by inhibiting proton pump in the gastric mucosa, and enhances the effects of the antibiotics (Sawacillin Tablets 250 and Flagyl Oral Tablets 250mg). Sawacillin Tablets 250 and Flagyl Oral Tablets 250mg show antibacterial actions against Helicobacter pylori.
It is usually used for Helicobacter pylori infection in gastric ulcer/duodenal ulcer/gastric MALT lymphoma/idiopathic thrombocytopenic purpura/the stomach after endoscopic treatment for early-stage gastric cancer, and Helicobacter pylori-associated gastritis.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are a patient with infectious mononucleosis, renal/hepatic disorder, blood disease (excluding idiopathic thrombocytopenic purpura) or brain/spinal cord disease.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet of Pariet Tablets 10mg (10 mg of Rabeprazole sodium), 3 tablets of Sawacillin Tablets 250 (750 mg [titer] of Amoxicillin hydrate) and 1 tablet of Flagyl Oral Tablets 250mg (250 mg of Metronidazole) at a time, twice a day for 7 days.
    Strictly follow the instructions.
  • Swallow the medicine without chewing or crushing.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Drinking alcohol may cause symptoms of hangover such as stomachache, vomiting or hot flush. Avoid taking alcohol while taking this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, itch, constipation, diarrhea, abdominal bloating, nausea, vomiting, loss of appetite, stomachache, taste abnormality, headache and fever. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • feeling unwell, sweating, breathing difficulty, rash, swelling of face, convulsion [shock, anaphylaxis]
  • dullness, fever, shortness of breath, nose/subcutaneous bleeding, reddish brown urine [pancytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, granulocytopenia, leukopenia]
  • yellowness in the skin or whites of the eyes, dullness, loss of appetite [fulminant hepatitis, hepatic function disorder, jaundice]
  • fever, dry cough, shortness of breath [interstitial pneumonia, eosinophilic pneumonia]
  • fever, general malaise, rash/redness in the skin/eyes/mouth [toxic epidermal necrolysis, mucocutaneous ocular syndrome, erythema multiforme, acute generalized exanthematous pustulosis, erythroderma]
  • decreased urine output, swelling of face/limbs, fever [acute kidney injury, interstitial nephritis]
  • nausea/vomiting, convulsion, headache, disturbance of consciousness [hyponatremia]
  • weakness, muscle pain, brown urine [rhabdomyolysis]
  • stomachache, frequent diarrhea, bloody stool [colitis]
  • numbness/pain/sensory paralysis in limbs [peripheral neuropathy]
  • convulsion, disturbance of consciousness, confusion [central nervous system damage]
  • stiffness in the neck, fever, headache, nausea/vomiting [aseptic meningitis]
  • stomachache, back pain, nausea/vomiting [acute pancreatitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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